Valuation: Silence Therapeutics plc

Market Cap 59Cr 80Cr 69Cr 64Cr 110.69Cr 7.62TCr 111.78Cr 757.39Cr 294.85Cr 3.85TCr 300.27Cr 293.73Cr 13TCr P/E 2026 *
-19.7x
P/E 2027 * -16.3x
Enterprise Value 45Cr 62Cr 53Cr 50Cr 86Cr 5.89TCr 86Cr 585.52Cr 227.94Cr 2.97TCr 232.13Cr 227.07Cr 9.85TCr EV / Sales 2026 *
1,396x
EV / Sales 2027 * 550x
Free-Float
69.35%
Yield 2026 *
-
Yield 2027 * -

Last Transcript: Silence Therapeutics plc

Manager TitleAgeSince
Chief Executive Officer 72 01/12/2025
Director of Finance/CFO 54 01/02/2022
Chief Tech/Sci/R&D Officer - 01/01/2021
Director TitleAgeSince
Director/Board Member 63 21/06/2018
Chairman 72 01/01/2004
Director/Board Member 65 05/05/2025
Change 5-day change 1-year change 3-year change Capi.($)
+1.02%+4.84%+4.80%+24.36% 5.12TCr
-0.09%-2.14%+492.60%+537.84% 4.53TCr
-0.32%+8.08%+37.97%+18.45% 4.28TCr
+1.18%+1.96%+21.95%+89.69% 4.23TCr
-2.27%-5.67%+14.55%+50.34% 3.22TCr
-0.96%+4.03%+31.55%+136.34% 1.73TCr
+0.41%+1.66% - - 1.65TCr
+1.12%+5.83%+8.37%+32.33% 1.48TCr
-0.31%+6.61%+81.37%+48.53% 1.43TCr
Average +0.00%+3.06%+86.64%+117.24% 3.08TCr
Weighted average by Cap. +0.10%+2.89%+105.43%+135.92%

Financials

2026 *2027 *
Net sales 3L 4L 4L 4L 6L 4.22Cr 6L 41.93L 16.32L 2.13Cr 16.63L 16.26L 7.05Cr 8L 10.23L 9L 8L 14.16L 9.76Cr 14.3L 96.92L 37.73L 4.92Cr 38.42L 37.59L 16Cr
Net income -4.14Cr -5.65Cr -4.84Cr -4.54Cr -7.82Cr -538.77Cr -7.9Cr -54Cr -21Cr -271.82Cr -21Cr -21Cr -900.19Cr -6.63Cr -9.04Cr -7.74Cr -7.26Cr -13Cr -861.56Cr -13Cr -86Cr -33Cr -434.68Cr -34Cr -33Cr -1.44TCr
Net Debt -13Cr -18Cr -16Cr -15Cr -25Cr -1.73TCr -25Cr -171.87Cr -67Cr -872.83Cr -68Cr -67Cr -2.89TCr -17Cr -24Cr -20Cr -19Cr -33Cr -2.26TCr -33Cr -224.74Cr -87Cr -1.14TCr -89Cr -87Cr -3.78TCr
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
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