Valuation: Silence Therapeutics plc

Market Cap 89Cr 118.67Cr 106.47Cr 98Cr 166.56Cr 11TCr 168.57Cr 1.18TCr 468.79Cr 5.91TCr 445.33Cr 435.93Cr 19TCr P/E 2026 *
-38.6x
P/E 2027 * -31.8x
Enterprise Value 76Cr 100.79Cr 90Cr 84Cr 141.46Cr 9.6TCr 143.17Cr 999.56Cr 398.13Cr 5.02TCr 378.21Cr 370.22Cr 16TCr EV / Sales 2026 *
2,303x
EV / Sales 2027 * 941x
Free-Float
69.35%
Yield 2026 *
-
Yield 2027 * -
1 day-0.35%
1 week+0.20%
Current month+80.33%
1 month+75.98%
3 months+70.65%
6 months+155.97%
Current year+224.18%
1 week 19.65
Extreme 19.65
19.86
1 month 8.66
Extreme 8.66
19.86
Current year 4.19
Extreme 4.19
19.86
1 year 4.19
Extreme 4.19
19.86
3 years 1.97
Extreme 1.97
27.72
5 years 1.97
Extreme 1.97
27.72
10 years 1.97
Extreme 1.97
35
Manager TitleAgeSince
Chief Executive Officer 72 01/12/2025
Director of Finance/CFO 54 01/02/2022
Chief Tech/Sci/R&D Officer - 01/01/2021
Director TitleAgeSince
Director/Board Member 63 21/06/2018
Chairman 72 01/01/2004
Director/Board Member 65 05/05/2025
Date Insider Type Main position Quantity % Market Cap. Importance
06/07/26 Sell 8,65,112 0.6105%
02/01/26 Free

Chief Financial Officer

3,75,000 0.2646%
02/01/26 Free

Director

90,000 0.0635%
Change 5-day change 1-year change 3-year change Capi.($)
-0.35%+0.20%+169.63%+176.83% 118.67Cr
+0.65%-3.36%+36.98%+60.50% 6.41TCr
+1.76%+1.27%+11.82%+81.21% 5.55TCr
-0.94%+0.99%+10.45%+100.19% 5.3TCr
+2.76%+0.87%+27.92%+55.07% 4.6TCr
+2.00%-3.39%+17.83%+119.04% 4.25TCr
+1.34%-2.86%+224.43%+914.08% 4.04TCr
+0.64%-3.95%+11.15%+45.57% 3.23TCr
+29.06%+47.63%+107.12%+92.73% 3.45TCr
-2.98%-0.62%+22.96%-10.93% 2.42TCr
Average +3.40%+3.69%+64.03%+163.43% 3.94TCr
Weighted average by Cap. +3.32%+3.48%+49.56%+159.69%

Financials

2026 *2027 *
Net sales 3L 4L 4L 4L 6L 4.17Cr 6L 43.4L 17.29L 2.18Cr 16.42L 16.08L 6.92Cr 8L 10.12L 9L 8L 14.21L 9.64Cr 14.38L 1Cr 39.99L 5.04Cr 37.99L 37.18L 16Cr
Net income -4.26Cr -5.67Cr -5.08Cr -4.7Cr -7.95Cr -539.72Cr -8.05Cr -56Cr -22Cr -282.43Cr -21Cr -21Cr -896.6Cr -6.49Cr -8.63Cr -7.75Cr -7.16Cr -12Cr -822.23Cr -12Cr -86Cr -34Cr -430.26Cr -32Cr -32Cr -1.37TCr
Net Debt -13Cr -18Cr -16Cr -15Cr -25Cr -1.7TCr -25Cr -177.4Cr -71Cr -891.47Cr -67Cr -66Cr -2.83TCr -18Cr -23Cr -21Cr -19Cr -33Cr -2.23TCr -33Cr -232.06Cr -92Cr -1.17TCr -88Cr -86Cr -3.7TCr
Projected Income Statement - Annual - Silence Therapeutics plc
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
Employees
88
Date Price Change Volume
28/26/28 $19.71 -0.35% 27,57,826
27/26/27 $19.78 0.00% 14,88,216
26/26/26 $19.78 +0.56% 46,54,224
23/26/23 $19.67 +0.05% 21,26,186
22/26/22 $19.66 -0.05% 30,78,639
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
-
MarketScreener Ratings - Silence Therapeutics plc
Sell
Consensus
Buy
Mean consensus
OUTPERFORM
Number of Analysts
5
Last Close Price
19.71USD
Average target price
19.75USD
Spread / Average Target
+0.20%

Quarterly revenue - Rate of surprise

Rate of surprise - Net sales - Quarterly - Silence Therapeutics plc