Xintela AB (publ) started its second clinical study (Phase I/IIa) with XSTEM® for the treatment of difficult-to-heal venous leg ulcers. XSTEM, which consists of allogeneic (donated) integrin 101-selected mesenchymal stem cells, is developed and manufactured by Xintela. The recruitment of patients for the Phase I/IIa study for the treatment of difficult-to-heal venous leg ulcers, which is carried out at Linköping University Hospital, has now begun.

Twelve patients with difficult-to-heal venous leg ulcers will receive a treatment of XSTEM or placebo applied to the wound and will then be followed up weekly for 10 weeks and after 6 months. The primary goal of the study is to show that the treatment is safe but also that XSTEM has a positive effect on wound healing. Early safety and efficacy data are expected before the end of 2022.