On November 29, 2022, Diffusion Pharmaceuticals Inc announced that the Company has sent the letter regarding the 2022 Annual General Meeting of shareholders, to be held on 30 November 2022. In addition, the Company urged the shareholders to vote at the Annual Meeting as LifeSci Special Opportunities Master Fund Ltd has notified the Company that it intends to nominate a slate of six nominees to stand for election as directors at the Annual Meeting in opposition to the nominees recommended by our Board of Directors. Further Company stated that the Board of Directors does not endorse any of LifeSci's nominees and unanimously recommends the shareholders to vote for each of the six nominees proposed by our Board of Directors on your enclosed white proxy card.