On November 18, 2022, LifeSci Special Opportunities Master Fund Ltd announced that it has sent an open letter to shareholders of Diffusion Pharmaceuticals Inc in response to CompanyÆs press release, highlighting CompanyÆs response against its discussions regarding potential strategic alternatives. In addition, LifeSci Special Opportunities Master Fund Ltd stated that it has nominated Jill Davidson, Tenzin Khangsar, Jeffrey Kimbell and urged the shareholders of the Company to vote for its board nominees at the annual meeting of shareholders scheduled to be held on December 30, 2022.