Centessa Pharmaceuticals plc announced a robust set of new preclinical data from in vivo and in vitro studies of its investigational, novel orexin receptor 2 (OX2R) agonist, ORX750, that support its potential best-in-class profile for the treatment of narcolepsy and other sleep- wake disorders. ORX750 is an investigational, orally administered, highly potent and selective orexin receptor 2 (ox2R) agonist designed to directly target the underlying pathophysiology of orexin neuron loss in narcolepsy type 1 (NT1). ORX750 is Centessa's first orexin product candidate being developed for the treatment of narcolpsy with potential expansion into other sleep- wake disorders.ORX750 is currently undergoing IND-enabling activities and has not been administered as an investigational drug to humans in any jurisdiction.

Any such statements that are not statements of historical fact may be deemed to be forward-looking statements, including statements related to: the Company's ability to deliver transformational medicines to patients; the activity significance of low doses in highly predictive, translational models of narcolepsy type 1 ("NT1") including maximal wake times and suppressed cataplexy at the lowest oral dose tested; the Company's expectations on the timing of Ind-enabling studies of ORX750 in narcolepsy and other Sleep- wake disorders; the ability of management team and board to drive execution of the Company's portfolio of programs; asset-centric business model and the intended advantages and benefits thereof; the scope, progress, results and costs of developing product candidates or any other future product candidates; current expectations concerning, amongst other things, the development and therapeutic potential and benefits of product candidates, including ORX750 and other OX2R agonists; strategy; regulatory matters, including the timing and likelihood of initiating clinical trials, reporting clinical trial results, ability to initiate or continue clinical trials or market any products; and the market size and opportunity for product candidates. Based on current expectations, estimates and projections only as of the date of this release and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set out in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to, risks related to the safety and tolerability profile of product candidates including ORX750; ability to protect and maintain intellectual property position; business (including commercial viability), regulatory, economic and competitive risks, uncertainties, contingencies and assumptions about the Company; risks inherent in developing product candidates and technologies; ability to obtain adequate financing, including through financing facility with Oberland, to fund planned clinical trials and other expenses; trends in the industry; the legal and regulatory framework for the industry, including the receipt and maintenance of clearances to conduct or continue clinical testing; future expenditures risks related to asset-centric corporate model; the risk that any one or more of product candidates will not be successfully developed and/or commercialized; and the risk that the results of non-clinical studies or clinical studies will not be predictive of future results.