Valuation: Centessa Pharmaceuticals plc

Market Cap 626.65Cr 550.39Cr 511.85Cr 469.69Cr 882.51Cr 60TCr 896.11Cr 6.08TCr 2.37TCr 30TCr 2.35TCr 2.3TCr 1,02600Cr P/E 2024
-8.13x
P/E 2025 -17.2x
Enterprise Value 609.03Cr 534.91Cr 497.46Cr 456.48Cr 857.69Cr 59TCr 870.92Cr 5.91TCr 2.31TCr 29TCr 2.29TCr 2.24TCr 1LCr EV / Sales 2024
-
EV / Sales 2025 23,18,10,355x
Free-Float
78.43%
Yield 2024 *
-
Yield 2025 -
1 day+0.80%
3 months+2.61%
6 months+60.27%
Current year+61.94%
Current year 21.5
Extreme 21.5
40.56
1 year 15.01
Extreme 15.01
40.56
3 years 5.15
Extreme 5.15
40.56
5 years 2.88
Extreme 2.885
40.56
10 years 2.88
Extreme 2.885
40.56
Manager TitleAgeSince
Chief Tech/Sci/R&D Officer - 01/10/2024
Chief Tech/Sci/R&D Officer 55 01/03/2023
Chief Administrative Officer 58 01/04/2021
Director TitleAgeSince
Director/Board Member - 24/06/2026
Director/Board Member - 24/06/2026
Date Insider Type Main position Quantity % Market Cap.
24/06/26 Issuer sale

Director

-3,92,474 0.2537%
24/06/26 Issuer sale

Director

-2,48,570 0.1606%
24/06/26 Issuer sale

Director

-2,32,000 0.1499%
Change 5-day change 1-year change 3-year change Capi.($)
+0.80%-.--%+162.82%+467.23% 626.65Cr
+1.07%-3.49%-3.35%+10.44% 4.69TCr
+0.25%+1.65%+399.22%+634.87% 4.02TCr
-0.27%+4.45%+11.81%+65.64% 3.62TCr
+0.35%+0.87%+4.46%-10.16% 3.47TCr
+3.14%+1.02%+4.76%+40.92% 2.79TCr
-0.73%+11.84%+34.39%+134.36% 1.68TCr
+0.47%-2.74% - - 1.67TCr
+0.42%-5.52%-3.43%+9.03% 1.31TCr
-2.68%-2.49%-11.36%-33.61% 1.27TCr
Average +0.28%+0.94%+66.59%+146.53% 2.52TCr
Weighted average by Cap. +0.49%+0.94%+76.78%+145.11%

Financials

2024 2025
Net sales - 15 13.17 12.25 11.24 21.12 1.44T 21.45 145.49 56.84 710.17 56.31 55.1 2.46T
Net income -24Cr -21Cr -19Cr -18Cr -33Cr -2.27TCr -34Cr -228.67Cr -89Cr -1.12TCr -89Cr -87Cr -3.86TCr -20Cr -17Cr -16Cr -15Cr -28Cr -1.9TCr -28Cr -191.59Cr -75Cr -935.21Cr -74Cr -73Cr -3.23TCr
Net Debt -36Cr -32Cr -30Cr -27Cr -51Cr -3.51TCr -52Cr -353.39Cr -138.07Cr -1.73TCr -136.78Cr -133.83Cr -5.96TCr -18Cr -15Cr -14Cr -13Cr -25Cr -1.7TCr -25Cr -170.9Cr -67Cr -834.21Cr -66Cr -65Cr -2.88TCr
Logo Centessa Pharmaceuticals plc
Centessa Pharmaceuticals plc is a clinical-stage pharmaceutical company. The Company is developing a new class of potential therapies within its orexin receptor 2 (OX2R) agonist program for the treatment of excessive daytime sleepiness (EDS), impaired attention, cognitive deficits, fatigue and other symptoms across neurological, neurodegenerative and neuropsychiatric disorders. It also has an early-stage immuno-oncology program focused on its LockBody technology platform. Its OX2R agonist pipeline includes ORX750, its advanced OX2R agonist development candidate, and ORX142, ORX489 and OX2R agonists in preclinical development. Its ORX750, an investigational, orally administered, highly potent and selective OX2R agonist, is in a Phase IIa study of participants with narcolepsy type 1 (NT1), NT2 and idiopathic hypersomnia (IH). ORX142 is the second OX2R agonist development candidate being advanced for the treatment of neurological and neurodegenerative disorders and other symptoms.
Employees
129
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