Then the COVID-19 pandemic happened. Vaccines that harness messenger RNA emerged as an effective protection against the virus, and hundreds of millions of people around the world were immunized with them. That has caused an explosion of interest in RNA, the nucleic acid that puts the genetic code into action and has a wide variety of other functions scientists are still working to grasp, said Moss, an associate professor of biochemistry, biophysics and molecular biology at
'Finding small bits of RNA sequences that can have medical significance has taken on much bigger importance now,' he said. 'It's gratifying to have that research getting closer to actually helping patients.'
The Moss lab was among nearly 50 RNA research groups to pitch a proposal for the CoSolve innovation challenge, part of
The partnership will combine the Moss lab's expertise in RNA structure, which recently has expanded to three-dimensional modeling, with
'When you get down to the essence of it, an RNA 3D structure is just a shape. It's got pockets and topography that create places where you should be able to stick therapeutic molecules,' he said.
Finding those molecular landing strips for drug compounds starts by analyzing RNA fragments in the human genome, looking for sequences that are more stable than expected. Such unusual stability suggests evolution has ordered the RNA sequence to fold in a special way, which may have biological importance. These exceptional sequences are then modeled to predict their shapes and tested virtually for their ability to bind drug molecules.
'You find a shape of interest and simulate putting millions of different molecules in these stable spots and wiggling them to see if they're a good fit,' Moss said.
Moss said he expects his team will learn a lot working with
'I really envision this as a two-way street,' he said.
The project will be the second time Moss has collaborated with a pharmaceutical company, following a two-year partnership with Eli
(C) 2024 Electronic News Publishing, source