Item 5.07 Submission of Matters to a Vote of Security Holders The annual meeting of shareholders of Vertex Pharmaceuticals Incorporated (the "Company") was held on May 19, 2021 (the "Annual Meeting"). Set forth below are the voting results for each of the proposals submitted to a vote of the Company's shareholders at the Annual Meeting: Proposal No. 1: Based upon the following votes, the shareholders elected Sangeeta Bhatia, Lloyd Carney, Alan Garber, Terrence Kearney, Reshma Kewalramani, Yuchun Lee, Jeffrey Leiden, Margaret McGlynn, Diana McKenzie and Bruce Sachs to serve as members of the Company's board of directors until the annual meeting of shareholders to be held in 2022:


                          For         Against      Abstain    Non-Votes
Sangeeta Bhatia       218,894,349     764,147      99,830     11,015,309
Lloyd Carney          171,495,897    48,046,438    215,991    11,015,309
Alan Garber           215,786,425    3,866,263     105,638    11,015,309
Terrence Kearney      212,942,050    6,706,475     109,801    11,015,309
Reshma Kewalramani    218,966,434     688,982      102,910    11,015,309
Yuchun Lee            215,699,823    3,940,932     117,571    11,015,309
Jeffrey Leiden        214,407,303    5,253,945     97,078     11,015,309
Margaret McGlynn      218,573,140    1,080,345     104,841    11,015,309
Diana McKenzie        219,445,405     208,565      104,356    11,015,309
Bruce Sachs           208,964,326    10,679,348    114,652    11,015,309

Proposal No. 2: Based upon the following votes, the shareholders ratified the appointment of Ernst & Young LLP as the Company's independent registered public accounting firm for the year ending December 31, 2021:

For Against Abstain Non-Votes

202,126,361 28,512,419 134,855 0

Proposal No. 3: Based upon the following votes, the shareholders approved, on an advisory basis, the 2020 compensation program for the Company's named executive officers:


        For         Against      Abstain    Non-Votes
    200,764,722    18,817,126    176,478    11,015,309

Proposal No. 4: The shareholder proposal was withdrawn by the proponent prior to the Annual Meeting. Proposal No. 5: The shareholder proposal was withdrawn by the proponent prior to the Annual Meeting.

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