TWi Biotechnology, Inc. announced that it has received approval from the Taiwan Food and Drug Administration (TFDA) to proceed a phase 2 clinical trial of AC-203 for the treatment of inherited Epidermolysis Bullosa (EB). This trial is designed to be a double-blind, intra-individual comparison, proof-of-concept clinical trial, and will enroll patients as young as 2 year old. The primary efficacy endpoint is the reduction of lesion surface in patients with EB. TWi Biotech expects the first patient will be enrolled in early April this year. AC-203 is a proprietary topical formulation of 1% diacerein, which has shown the ability to inhibit the production and activity of caspase-1 and the cytokine Interleukin-1Beta (IL-1Beta) through the inhibition of the assembly of the NLRP3 inflammasome. Inhibition of the NLRP3 inflammasome associated signaling pathway and IL-1Beta has been demonstrated to be effective in treating a variety of diseases including arthritis, gout, and diabetes mellitus (DM).