Seer Inc.; SCIEX; and Discovery Life Sciences (Discovery) announced they have signed an agreement to form the Proteogenomics Consortium, a collaboration that will enable genomics customers to more easily add deep, unbiased proteomics data to their discovery, translational and clinical studies. Through this multi-year effort, Discovery will establish, expand, and offer deep, unbiased proteomics capabilities to their existing genomics customers using the Seer Proteograph Product Suite and the SCIEX ZenoTOF 7600 platform. This will create a capacity for more than one billion peptides each year to be analyzed and cataloged, allowing the discovery of new protein variants and novel biomarkers, potentially leading to therapeutic breakthroughs.

Seer and SCIEX will contribute proprietary proteomics technologies and instrumentation, and Discovery will provide its significant scale and expertise in genomics services and biospecimens, to provide services that support population-scale plasma proteogenomic projects. Seer's Proteograph Product Suite includes proprietary engineered nanoparticles, consumables, an automation instrument, and software that enables deep, unbiased proteomics studies with an unprecedented combination of speed, scale, depth, and breadth of data. It accurately surveys thousands of proteins and millions of peptides with precision.

The SCIEX ZenoTOF 7600 system is a high-resolution, accurate mass system combining the power of Zeno trap pulsing with electron activated dissolution (EAD) fragmentation technology to uncover structural information, previously inaccessible, and drive the limits of quantification achievable with accurate mass. Discovery will expand their existing biomarker discovery platform as part of their proteomics strategy, expanding the technology platforms available to their worldwide customer base. Their unique service-oriented scientific team will deliver reliable scientific insight for proteogenomic studies.

The Proteogenomics Consortium aims to significantly expand understanding of the proteome in an unbiased manner across a variety of cohorts and disease states. With a phased approach to building a 100,000 sample per-year capacity, the Proteogenomics Consortium plans to create the workflows and expertise to run large-scale proteogenomic projects efficiently, quickly, and robustly. Through the Consortium there is also an opportunity for future collaborations to further pave the way for adoption of proteogenomics via workflow optimization and joint publications.