Exhibit 99.3

4th Quarter Earnings Conference Call

January 22, 2021

2020 overview

4Q20

FY 2020

$588M $991M

$0.61 $1.03

$1,655M $6,206M

$930M $3,541M

$725M $2,665M

(1) Non-GAAP, see appendix for reconciliation.

Net Income Available to Common Shareholders

Diluted Earnings Per

Share

Adjusted Total

Revenue(1)

Adjusted Non-

Interest Expense(1)

Adjusted Pre-Tax Pre-

Provision Income(1)

Generated highest adjusted pre-taxpre-provision income(1) in over a decade providing opportunity to contribute another $10M to the Regions Foundation

2

Average loans

Adjusted average loans and leases(1)

($ in billions)

$78.6

$82.0

$80.1

27.3

27.4

26.6

52.0

54.7

52.7

4Q19 3Q20 4Q20

Adjusted business loans(1)

Adjusted consumer loans(1)

(1) Non-GAAP, see appendix for reconciliation.

QoQ highlights & outlook

  • Average loans decreased 3%; adjusted average loans(1) decreased 2%
  • Commercial line utilization levels reached historical low, ending quarter just under 40%
  • Despite improving pipelines, utilization is expected to remain muted through the first half of 2021
  • Active portfolio management; $408M of commercial loans sold or transferred to HFS in 4Q
  • PPP forgiveness drove a $415M reduction in average loan balances
  • Mortgage production finished the year strong, with FY 2020 more than doubling 2019 levels
  • Expect 2021 adjusted average loans to be down low single digits compared to 2020; and adjusted ending loans are expected to grow low single digits

3

Average deposits

Average deposits by segment

($ in billions)

$116.7

$119.8

0.4

0.4

8.9

8.7

$94.5

0.6

38.8

40.6

7.9

26.6

59.4

68.8

69.9

4Q19

3Q20

4Q20

Consumer Bank

Corporate Bank

Wealth Mgt

Other(1)

QoQ highlights & outlook

  • Average and ending deposits increased 3%
  • Full-yearaverage deposits 17% higher than 2019
    • Growth predominately in non- interest bearing core operating accounts across all three business segments
    • Growth driven primarily by higher balances; also experiencing strong account growth
  • Expect near-term deposit balances will continue to increase, particularly as the second round of stimulus is disbursed

(1) Other deposits represent non-customer balances primarily consisting of wholesale funding (for example, Eurodollar deposits, selected deposits

4

and brokered time deposits).

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Regions Financial Corporation published this content on 22 January 2021 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 22 January 2021 18:49:01 UTC