Lexston Life Sciences Corp. announced that the company's scientific research and development division led by Chief Science Officer, Dr. Philippe Henry, has begun work on its tryptamine pipeline with an initial focus on 5-Methoxy-N, N-dimethyltryptamine (5-MeO-DMT) at its newly acquired Zenalytic Laboratories. With confirmation from Health Canada's Controlled Substances Directorate to proceed with characterization work on the target molecule, 5-MeO-DMT, the company's scientists have moved ahead with its plans to develop methods for the identification and quantification of this target tryptamine. The company has also successfully developed a High Pressure Liquid Chromatography (HPLC) assay for the determination and purity of 5-MeO-DMT, thus paving the way for future product development activities. Additionally, it has successfully collected Near-Infrared spectra (NIRs) from the purified substance to develop a portable rapid technique for the identification and quantification of tryptamine formulations at the point-of-care. the company is exploring different naturally derived botanical sources of 5-MeO-DMT, the use of different solvents and delivery systems for a formulation of a sub-psychoactive dosage. Based on its neuro-vasocontraction abilities this formulation will be used in conjunction with clinical partners specifically targeted for the alternative treatment of migraines and cluster headaches. In support of clinical applications, the Lexston team is also collecting serotonin and other receptor affinity data for 5-MeO-DMT, its metabolites and other closely related tryptamines. 5-MeO-DMT possesses unique pharmacodynamic and pharmacokinetic properties imparted by its specificity for serotonin receptors 5HT-1a,7,6,1d and dopamine D1. Unravelling the mechanism underlying the mode of action of this tryptamine is expected to shed light on potential novel treatments for major depressive disorders and addiction.