On January 23, 2021, Kelvin Neu notified IGM Biosciences, Inc. of his resignation from the Company's board of directors, which resignation was effective as of January 26, 2021 and was not due to any disagreement with the Company on any matter related to the Company's operations, policies or practices. On January 24, 2021, Felix J. Baker, Ph.D. was appointed to the Board to serve as a Class III director, with a term beginning on January 26, 2021 and expiring at the Company's 2022 annual meeting of the stockholders. Dr. Baker will serve on the Board as the designee of 667, L.P. and Baker Brothers Life Sciences, L.P. pursuant to that certain Nominating Agreement, dated as of June 28, 2019, by and between the Company and the Baker Bros.