Fuse Science, Inc. announced their Round II Research results that have shown their proprietary delivery technology has successfully delivered therapeutic doses of varying-size compounds directly through the epidermis. During the company's Round I Research conducted in 2012, caffeine was delivered effectively through the epidermis. This initial study provided four basic principles surrounding Fuse Science's proprietary technology: speed, variability, duration and functionality.

The Round II Research results expanded the prior proof of concepts by showing Fuse's proprietary delivery technology successfully delivering numerous Active Pharmaceutical Ingredients (API's) of varying size, rigidity and lipophilicity, whether it is fat or water soluble, directly through the epidermis. Nine Fuse Science formulations were tested in an ex vivo penetration study through human epidermis. Eight compounds were tested with the proprietary encapsulation technology and one of them was tested with a second proprietary encapsulation formulation.

Fuse Science's proprietary technology delivered Insulin, Paclitaxel, Estradiol, Nicotinic Acid, Folic Acid, Polyethylene Glycol (PEG), Vitamin E Acetate and caffeine with 100% success rate. Insulin, one of the compounds previously analyzed, is a reliable proof of principle for the technology. Because it is such a large molecule, and a protein, it has been traditionally very difficult to deliver through the skin unless it was given via an injection.

During this study, it passed through even at low concentrations in the Company's proprietary formulation. In addition, two other large-market drugs Estradiol, used to treat the symptoms of menopause and Paclitaxel, a prescription cancer drug, were tested. It is Fuse's hypothesis, based on the success of their research, that they will be successful in the delivery of therapeutic doses of each, within their matrix, in a simple roll-on application.

The primary benefits that may develop from these studies are: Enhanced delivery option for complex API's; Improved bio-availability or enhanced absorption in the body; Stronger product efficacy; Enhanced ease of use (A simple roll-on application); Expansion of therapeutic options for acute, rapid onset conditions. Data from these preliminary research studies show that with little requirement for optimization, the technology can provide for the transdermal delivery of drugs at clinically relevant doses for the treatment of a wide variety of ailments and diseases. Most compounds showed improvement of delivery over each time-point during the course of the study.

The lack of plateaus would suggest that delivery improves with time and can be sustained for periods much greater than twenty-four hours.