Effective as of January 15, 2019, Robert R. Ruffolo, Jr. resigned from the board of directors of Diffusion Pharmaceuticals Inc. Mr. Ruffolo served as the Chairman of the Science and Technology Committee of the Board prior to his resignation. Mr. Ruffolo indicated that his decision to resign was due to his desire to focus on other personal pursuits and was not the result of any disagreement with the company, the company's management or the Board.