Defence Therapeutics Inc. announced that it signed an agreement with City of Hope National Medical Center and Beckman Research Institute of the City of Hope, one of the best and most renowned Cancer Institute Hospital in the US, to oversee its IND submission for a Phase I clinical trial of AccuTOXTM in solid cancer. City of Hope is a worldwide renowned center dedicated to translating experimental treatments into cures for various illnesses. The center has more than 11,000 personnels, healthcare professionals and support staff all united to funnel new findings into clinical trials.

City of Hope, one of the largest cancer research and treatment organizations in the United States, was recognized as the seventh "Best Hospital" for cancer in the nation according to U.S. News & World Report's 2022-23 Best Hospitals: Specialty Ranking. City of Hope will prepare the IND package and eFiling for Defence's AccuTOXTM cancer program, conduct the clinical and the biostatistical study design, review all preclinical and GLP studies to draft a study protocol and investigator's brochure in addition to managing and overseeing all project-related objectives. Over the last 16 months, the Defence team efficiently completed all preclinical and GLP studies related to the AccuTOXTM molecule as an injectable for solid tumors.

The results showed that the drug can halt tumor growth and synergize with multiple immune-checkpoint inhibitors and it demonstrated as well that the AccuTOXTM compound is safe and well tolerated using both rodents and canine animal models.