Clinuvel Pharmaceuticals : Change of Director's Interest Notice

CompanyAnnouncement

ASX:

CUVNasdaq International Designation: CLVLYXETRA-DAX:

UR9

Appendix 3Y- Change of Director's Interest Notice

Melbourne, Australia 29 January 2019

The followingAppendix 3Y Change of Director's Interest Notice relates to a notifiable interest in CLINUVELPHARMACEUTICALS LTD for Mrs Brenda Shanahan.

There has been no recent trading activity by Mrs Shanahan but the updated notice now includes 80,000 shares held in a charitable foundation of which Mrs Shanahan is a Trustee. Mrs Shanahan'smost recentdirector's interest noticewas disclosed 5thAugust 2016.

-End-

For more information contact:

Darren Keamy, Company Secretary CLINUVEL PHARMACEUTICALS LIMITED

Level 6, 15 Queen Street T [phone]www.clinuvel.comMelbourne, Victoria, Australia 3000 F [phone]

Investor enquiries

[e-mail]

About CLINUVEL PHARMACEUTICALS LIMITED

CLINUVEL PHARMACEUTICALS LTD (ASX: CUV; NASDAQ INTERNATIONAL DESIGNATION ADR: CLVLY; XETRA-DAX: UR9) is a global biopharmaceutical company focused on developing and delivering treatments for patients with a range of severe genetic and skin disorders. As pioneers in photomedicine and understanding the interactionof light and human biology, CLINUVEL's research and development has led to innovative treatments for patient

populations with a clinical need for photoprotection and repigmentation. These patient groups range in size from5,000 to 45 million worldwide. CLINUVEL's lead compound, SCENESSE®(afamelanotide 16mg), was approved by

the European Commission in 2014 for the prevention of phototoxicity (anaphylactoid reactions and burns) in adult patients with erythropoietic protoporphyria (EPP). More information on EPP can be found athttp://www.epp.care.

Headquartered in Melbourne, Australia, CLINUVEL has operations in Europe, Switzerland, the US and Singapore, with the UK acting as the EU distribution centre.

For more information go tohttp://www.clinuvel.com.

SCENESSE®is a registered trademark of CLINUVEL PHARMACEUTICALS LTD.

Forward-Looking Statements

This release contains forward-looking statements, which reflect the current beliefs and expectations of CLINUVEL's

management. Statements may involve a number of known and unknown risks that could cause our future results, performance or achievements to differ significantly from those expressed or implied by such forward-looking statements. Important factors that could cause or contribute to such differences include risks relating to: our ability to develop and commercialise pharmaceutical products, including our ability to develop, manufacture, market and sell biopharmaceutical products; competition for our products, especially SCENESSE®(afamelanotide 16mg); our ability to achieve expected safety and efficacy results through our innovative R&D efforts; the effectiveness of ourpatents and other protections for innovative products, particularly in view of national and regional variations in patent laws; our potential exposure to product liability claims to the extent not covered by insurance; increased government scrutiny in either Australia, the U.S., Europe and Japan of our agreements with third parties and suppliers; our exposure to currency fluctuations and restrictions as well as credit risks; the effects of reforms in healthcare regulation and pharmaceutical pricing and reimbursement; that the Company may incur unexpected delays in the outsourced manufacturing of SCENESSE®which may lead to it being unable to supply its commercial markets and/or clinical trial programs; any failures to comply with any government payment system (i.e. Medicare) reporting and payment obligations; uncertainties surrounding the legislative and regulatory pathways for the registration and approval of biotechnology based products; decisions by regulatory authorities regarding approval of our products as well as their decisions regarding label claims; any failure to retain or attract key personnel and managerial talent; the impact of broader change within the pharmaceutical industry and related industries; potential changes to tax liabilities or legislation; environmental risks; and other factors that have been discussed in our 2018 Annual Report. Forward-looking statements speak only as of the date on which they are made and the Company undertakes no obligation, outside of those required under applicable laws or relevant listing rules of the Australian Securities Exchange, to update or revise any forward-looking statement, whether as a result of new information, future events or otherwise. More information on the forecasts and estimates is available on request. Past performance is not an indicator of future performance.

Level 6, 15 Queen Street Melbourne, Victoria 3000 Australia

T [phone]

www.clinuvel.com

F [phone]

Rule 3.19A.2

Appendix 3Y

Change of Director's Interest Notice

Information or documents not available now must be given to ASX as soon as available.

Information and documents given to ASX become ASX's property and may be made public.

Introduced 30/09/01 Amended 01/01/11

Name of entity

ABNCLINUVEL PHARMACEUTICALS LTD 88 089 644 119

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Brenda Shanahan
Date of last notice	05 August 2016

Part 1 -Change of director's relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In thecase of a company, interests which come within paragraph (i) of the definition of "notifiable interest of a director" shouldbe disclosed in this part.

Direct or indirect interest	Indirect Interest
Nature of indirect interest (including registered holder) Note: Provide details of the circumstances giving rise to the relevant interest.	Brenda Shanahan Charitable Foundation of which the director is a Trustee to the foundation
Date of change	2 September 2008
No. of securities held prior to change	1. 53,969 Ordinary Shares (San Luis Nominees Pty Ltd) 2. 100,000 Ordinary shares (Clinuvel Conditional Performance Rights Scheme Trust ) 50,000 Unlisted Conditional Performance Rights
Class	Ordinary Shares
Number acquired	80,000 Ordinary Shares
Number disposed	Nil
Value/Consideration Note: If consideration is non-cash, provide details and estimated valuation	$201,650.00
No. of securities held after change	1. 53,969 Ordinary Shares (San Luis Nominees Pty Ltd) 2. 100,000 Ordinary shares (Clinuvel Conditional Performance Rights Scheme Trust ) 3. 80,000 Ordinary shares 50,000 Unlisted Conditional Performance Rights
Nature of change Example: on-market trade, off-market trade, exercise of options, issue of securities under dividend reinvestment plan, participation in buy-back	on market acquisition

Part 2- Change of director's interests in contracts

Note:In the case of a company, interests which come within paragraph (ii) of the definition of "notifiable interest of a director" should bedisclosed in this part.

Detail of contract

Nature of interest

Name of registered holder (if issued securities)

Date of change

No. and class of securities to which interest related prior to change Note: Details are only required for a contract in relation to which the interest has changed

Interest acquired

Interest disposed

Value/Consideration Note: If consideration is non-cash, provide details and an estimated valuation

Interest after change

Part 3-+Closed period

Were the interests in the securities or contracts detailed above traded during a+closed period where prior written clearance was required?	No
If so, was prior written clearance provided to allow the trade to proceed during this period?	n/a
If prior written clearance was provided, on what date was this provided?	n/a