Item 7.01 Regulation FD Disclosure.
Verve further reported that the "new data demonstrate that in vivo base editing of the PCSK9 gene in the liver of non-human primates resulted in durable and consistent lowering of blood LDL-C and blood PCSK9 protein levels following a single course of treatment. In the studies, a single intravenous infusion achieved a 59% reduction in blood LDL-C at two weeks, which has been maintained at six months post treatment. LDL-C reduction over this time period averaged 61% [figure omitted]. During this same six-month time period, the average blood PCSK9 protein level was reduced by 89%."
According to Verve, its "gene editing treatment was well tolerated with no adverse events reported during the study. In studies of primary human hepatocytes, clear evidence of on-target editing was observed with no evidence of off-target editing."
The Company and Verve entered into a collaboration and license agreement in
The information in this Form 8-K is being furnished and shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference into any filing by the Company, under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such filling.
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