Item 1.01. Entry into a Material Definitive Agreement.

On January 4, 2021, Arvinas Operations, Inc. (the "Company"), a wholly-owned subsidiary of Arvinas, Inc. (the "Registrant"), entered into a Fifth Amendment to Lease (the "Fifth Lease Amendment") with Science Park Development Corporation (the "Landlord"), which amends that certain Lease, dated as of December 31, 2017 (as amended, the "2017 Lease"), by and between the Company and the Landlord, for office and laboratory space in New Haven, Connecticut (the "2017 Leased Premises"). The Fifth Lease Amendment expands the 2017 Leased Premises to include approximately an additional 10,000 rentable square feet for a total of approximately 60,000 rentable square feet, extends the term of the 2017 Lease to December 31, 2024, and increases the monthly base rent for the period of January 2023 to December 2024 to $116,469.91. The other material terms of the 2017 Lease (including the monthly base rent for the period until December 2022) remain unchanged.

In addition, on January 4, 2021, the Company entered into a Second Amendment to Lease (the "Second Lease Amendment") with Landlord, which amends that certain Lease, dated as of November 15, 2019 (as amended, the "2019 Lease"), by and between the Company and the Landlord, for office and laboratory space in New Haven, Connecticut (the "2019 Leased Premises"). The Second Lease Amendment extends the term of the 2019 Lease to December 31, 2024 and increases the monthly base rent for the period of January 2023 to December 2024 to $6,893.33. In addition, the Second Lease Amendment corrects a scrivener's error in the 2019 Lease to reflect the correct annual base rent per rentable square foot of $21.00 for the period of June 1, 2020 to December 31, 2022. The other material terms of the 2019 Lease remain unchanged.

The foregoing descriptions of the Fifth Lease Amendment and Second Lease Amendment do not purport to be complete and are qualified in their entirety by reference to the Fifth Lease Amendment and Second Lease Amendment, copies of which the Registrant intends to file with the Securities and Exchange Commission as exhibits to the Registrant's Annual Report on Form 10-K for the year ended December 31, 2020.

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