- TUS+VEN+HMA Triplet Protocol in 1L Therapy for Newly Diagnosed AML was Submitted to the FDA During Q1 and is Now Being Activated at Clinical Sites
- TUS+VEN+HMA Triplet 1L Therapy for Newly Diagnosed AML is Supported by Extensive TUS and TUS+VEN Data from Completed Trials with R/R AML
- Conference Call and Webcast at
5:00 pm ET Today
“Tuspetinib (TUS) has now moved to triplet frontline (1L) treatment for newly diagnosed (ND) acute myeloid leukemia (AML) patients who need a superior 1L therapy. The introduction of venetoclax (VEN) to establish the venetoclax/hypomethylating agent (VEN+HMA) doublet was a major advancement in the frontline treatment of ND AML, but response rates still remain too low and survival too short in 1L therapy. Even more concerning, patients who fail a VEN-containing regimen respond poorly to subsequent salvage therapies in the relapsed or refractory (R/R) setting and have a dismal prognosis,” said
Key Corporate Highlights
- Tuspetinib Advancement to TUS+VEN+HMA Triplet Therapy Supported by Extensive Dose Exploration as TUS Single Agent and TUS+VEN Doublet – Tuspetinib, a convenient once daily oral agent that potently targets SYK, FLT3, mutated KIT, JAK1/2, and RSK2 kinases, is being developed for the treatment of patients with ND AML. Tuspetinib avoids many typical toxicities observed with other agents, showing no treatment related QTc prolongation or CPK elevations; no differentiation syndrome; and no drug-related myelosuppression during remission with no drug-related discontinuations or deaths. In the APTIVATE trial, Tuspetinib achieved broad activity across AML patients with a diversity of adverse genetics as a single agent (TUS) and in combination with venetoclax (TUS+VEN) in very ill relapsed/refractory (R/R) and heavily pre-treated AML populations. Blast reductions and responses were observed in patients with Prior-VEN, Prior-FLT3 inhibitor (FLT3i), and Prior-HSCT therapies, those with highly adverse genetics, including mutations in TP53 and RAS genes, and those with mutated or unmutated FLT3 genes. Patients naïve to VEN therapy achieved higher response rates.
- Tuspetinib Protocol Now Ready for Triplet Therapy Pilot Study; Clinical Sites Being Activated – Tuspetinib is the ideal third agent for a 1L triplet because of its distinctly favorable safety profile. Tuspetinib enhances antileukemic activity when combined with VEN or HMA in pre-clinical models, Tuspetinib has demonstrated a broad scope of activity across genetic subgroups of AML, and Tuspetinib mechanistically cooperates with VEN to thwart drug resistance. The protocol was submitted to the
U.S. Food and Drug Administration (FDA) in Q1, more than 45 days ago, and is currently being activated at clinical sites to initiate the TUS+VEN+AZA triplet pilot study. The new study will enroll ND AML patients who are ineligible to receive intensive induction chemotherapy due to age or co-morbidity. By definition, study participants will be VEN-naïve, FLT3i-naïve, and HMA-naïve, a group that has been shown to be highly responsive to triplet regimens. However, current triplet therapies containing kinase inhibitors can be limited by toxicities often requiring dose reductions of all three agents and are not being pursued in the larger FLT3-unmutated AML population. Clinical sites are now preparing to open the TUS+VEN+HMA triplet study, which is expected to commence enrollment early next quarter. Initial data are expected in the fourth quarter of this year.
- Tuspetinib Abstract Accepted for Poster Presentation at EHA – Aptose will deliver a clinical poster presentation at the
European Hematology Association (EHA) 2024Hybrid Congress inMadrid, Spain (Poster ID # P557) that describes the safety and efficacy of tuspetinib (TUS) monotherapy and the TUS+VEN doublet in the APTIVATE Phase 1/2 trial with R/R AML patients. The data illustrate the safety and breadth of activity of TUS and TUS+VEN and support our launch of the TUS+VEN+HMA triplet frontline therapy in newly diagnosed AML. A separate preclinical abstract, which has been accepted for e-poster publication, demonstrates that TUS retains nanomolar potency against AML cells engineered to express the NRAS-G12D mutation or selected for resistance to venetoclax (Poster ID # P1756).
- Tuspetinib Preclinical Studies Elucidate Mechanistic Cooperativity Among TUS and VEN – Aptose continues to investigate the mechanisms underlying the complementary activity between TUS and VEN. In addition to targeting certain VEN resistance mechanisms, TUS retains activity against VEN-resistant AML cell lines. Likewise, resistance to TUS creates a synthetic lethality for VEN with a 2000-fold increase in sensitivity to VEN. Other studies demonstrate TUS retains potent antitumor activity in preclinical models of human AML resistant to the gilteritinib FLT3 inhibitor (FLT3i), a finding that is clinically validated by response rates to TUS in R/R AML study participants with prior FLT3i treatment.
- Nasdaq – On
February 29, 2024 , Aptose received a deficiency letter from the Listings Qualifications Department ofThe Nasdaq Stock Market LLC (“Nasdaq”) regarding the previously announced private placement withHanmi Pharmaceutical, Inc. (“Hanmi”) which closed inJanuary 2024 . In response to the deficiency letter, Aptose submitted a plan to Nasdaq to regain compliance. OnApril 25, 2024 , the Company received confirmation from Nasdaq that the Company had regained compliance with Nasdaq Listing Rule 5635(d) and determined that the matter is now closed. Pursuant to the Company’s plan to regain compliance, onApril 26, 2024 , the Company announced that it had amended the terms of the warrant agreement with Hanmi to prohibit the exercise of the warrants if such exercise would result in Hanmi owning more than 19.99% of the issued and outstanding shares of Aptose, unless shareholder approval is first obtained.
- On
April 2, 2024 , Aptose received a second Notification Letter from Nasdaq stating that the Company was not in compliance with Nasdaq’s listing rules because the stockholders’ equity as ofDecember 31, 2023 , was below the minimum requirement of$2.5 million . The shareholder’s equity as ofDecember 31, 2023 was negative$2.9 million . As ofMarch 31, 2024 , the shareholder’s equity is$137,000 , positive. Aptose intends to submit a compliance plan on or beforeMay 17, 2024 , to monitor stockholders’ equity and, if appropriate, consider further available options to evidence compliance with the requirement.
Multiple Planned Value-creating Milestones Ahead
- TUS and TUS+VEN data in R/R AML to support TUS+VEN+HMA in ND AML: EHA 2024
- Triplet pilot dose initiation planned in ND AML: Summer 2024
- Triplet pilot dose escalation planned with early CR/MRD/safety data in ND AML: ASH 2024
- Triplet pilot completed with CR/MRD data and dose selection: EHA 2025
- Triplet Ph2/Ph3 pivotal program planned initiation: 2H 2025
FINANCIAL RESULTS OF OPERATIONS
Statements of Operations Data (unaudited) ($ in thousands, except per share data) | |||||||
Three months ended | |||||||
2024 | 2023 | ||||||
Expenses: | |||||||
Research and development | $ | 6,445 | $ | 8,811 | |||
General and administrative | 3,315 | 5,285 | |||||
Operating expenses | 9,760 | 14,096 | |||||
Other income, net | 120 | 420 | |||||
Net loss | $ | (9,640 | ) | $ | (13,676 | ) | |
Net Loss per share, Basic and diluted | $ | (0.73 | ) | $ | (2.22 | ) | |
Weighted average number of common shares outstanding used | |||||||
in computing net loss per share, basic and diluted (in thousands) | 13,133 | 6,171 | |||||
The net loss for the three months ended
The decrease in net loss for the three months ended
Balance Sheet Data (unaudited) ($ in thousands) | ||||||||
2024 | 2023 | |||||||
Cash, cash equivalents and short-term investments | $ | 9,328 | $ | 9,252 | ||||
Working capital | (318 | ) | (3,375 | ) | ||||
Total assets | 12,796 | 12,989 | ||||||
Long-term liabilities | 520 | 621 | ||||||
Accumulated deficit | (525,177 | ) | (515,537 | ) | ||||
Stockholders’ equity | 137 | (2,901 | ) | |||||
- Total cash and cash equivalents and investments as of
March 31, 2024 , were$9.3 million . Based on current operations, the Company expects that cash on hand and available capital provides the Company with sufficient resources to fund planned Company operations including research and development through August of 2024.
- Common shares outstanding on
May 14, 2024 , were 16,309,393.
RESEARCH AND DEVELOPMENT EXPENSES
The research and development expenses for the three months ended
Three months ended | ||||||
(in thousands) | 2024 | 2023 | ||||
Program costs – Tuspetinib | $ | 3,923 | $ | 4,774 | ||
Program costs – Luxeptinib | 208 | 1,289 | ||||
Program costs – APTO-253 | 22 | 8 | ||||
Personnel related expenses | 1,954 | 2,078 | ||||
Stock-based compensation | 328 | 652 | ||||
Depreciation of equipment | 10 | 10 | ||||
Total | $ | 6,445 | $ | 8,811 | ||
Research and development (“R&D”) expenses decreased by
- Program costs for tuspetinib were
$3.9 million for the three-month period endedMarch 31, 2024 , compared with$4.7 million in the comparative period in 2023. The lower program costs for tuspetinib in the current period represent the near completion of our APTIVATE clinical trials, and reduced manufacturing costs. In the comparative period in 2023, tuspetinib program costs included the healthy volunteer study, which was completed in 2023.
- Luxeptinib program costs were
$208,000 and decreased by approximately$1.1 million , primarily due to lower clinical trial and manufacturing costs associated with the conclusion of certain luxeptinib clinical trial activities.
- Program costs for APTO-253 were
$22,000 . The Company decided onDecember 20, 2021 to discontinue further development of APTO-253.
- Stock-based compensation decreased by approximately
$324,000 in the three months endedMarch 31, 2024 , compared to the three months endedMarch 31, 2023 , primarily due to stock options granted with lower grant date fair values, in the current period.
Conference Call & Webcast:
Date: | |
Time: | |
Webcast Only (will include slides): | link (https://edge.media-server.com/mmc/p/bm3d3k5a/) |
Q&A Participant Registration Link*: | link (https://register.vevent.com/register/BIebf7d306b67a4388b6a8d9cc63464f80) |
*Analysts interested in participating in the question-and-answer session will pre-register for the event from the participant registration link above to receive the dial-in numbers and a unique PIN, which are required to access the live conference call. They also will have the option to take advantage of a Call Me button and the system will automatically dial out to connect to the Q&A session.
The webcast also can be accessed through a link on the Investor Relations section of Aptose’s website here. A replay of the webcast will be available on the company’s website for 30 days.
The press release, the financial statements and the management’s discussion and analysis for the quarter ended
About Aptose
Forward Looking Statements
This press release contains forward-looking statements within the meaning of Canadian and
Should one or more of these risks or uncertainties materialize, or should the assumptions set out in the section entitled "Risk Factors" in our filings with Canadian securities regulators and the
For further information, please contact:
617-430-7576 | |
201-923-2049 | Daniel@LifeSciAdvisors.com |
spietropaolo@aptose.com |
Source:
2024 GlobeNewswire, Inc., source