On August 25, 2022, Zymergen Inc. announced a further reduction in force that is expected to result in the termination of approximately 80 additional employees. The company estimates it will incur cash-based severance costs of approximately $3.8 million related to the August 2022 Reduction in Force and an aggregate of approximately $7.4 million in cash-based severance costs when combined with the initial reduction in force. The company also expects to incur stock-based compensation and employee restructuring costs related to these reductions in force, the amount of which has not yet been estimated.