BUSINESS OVERVIEW





We are a biopharmaceutical company focused on advancing innovative
immune-oncology technologies addressing hard to treat cancers. Our DNase
platform is designed to improve outcomes of existing treatments, including
immunotherapies, by targeting NETs. We licensed the DNase oncology platform in
April 2022 and expect to prioritize our efforts and resources on the development
of this newly acquired technology. We are currently focused on advancing our
systemic DNase program into the clinic as an adjunctive therapy for pancreatic
carcinoma and locally advanced or metastatic solid tumors. We are also
developing our personalized Chimeric Antigen Receptor ("CAR") T platform
technology, XCART™, to develop cell-based therapeutics targeting the unique
B-cell receptor on the surface of an individual patient's malignant tumor cells,
for the treatment of B-cell lymphomas. Additionally, we have partnered with
biotechnology and pharmaceutical companies to develop our proprietary drug
delivery platform, PolyXen, and receive royalty payments under an exclusive
license arrangement in the field of blood coagulation disorders.



We incorporate our patented and proprietary technologies into drug candidates
currently under development with biotechnology and pharmaceutical industry
collaborators to create what we believe will be the next-generation biologic
drugs with improved pharmacological properties over existing therapeutics. Our
drug candidates have resulted from our research activities or that of our
collaborators and are in the development stage. As a result, we continue to
commit a significant amount of our resources to our research and development
activities and anticipate continuing to do so for the near future. To date, none
of our drug candidates have received regulatory marketing authorization or
approval in the U.S. by the Food and Drug Administration ("FDA") nor in any
other countries or territories by any applicable agencies. We are receiving
ongoing royalties pursuant to a license of our PolyXen technology to an industry
partner. Although we hold a broad patent portfolio, the focus of our internal
efforts during the year ended December 31, 2022, was on the licensing and
advancement of our DNase platform and on the development of our XCART platform
technology.


Critical Accounting Policies and Estimates





The preparation of our financial statements in conformity with U.S. generally
accepted accounting principles ("U.S. GAAP") requires us to make estimates,
judgments and assumptions that affect the reported amounts of assets and
liabilities at the date of the financial statements and the reported amounts of
revenue, costs and expenses during the reporting period. On an ongoing basis, we
evaluate our estimates that are based on historical experience and on various
other assumptions that we believe to be reasonable under the circumstances. The
result of these evaluations forms the basis for making judgments about the
carrying values of assets and liabilities and the reported amount of expenses
that are not readily apparent from other sources. Because future events and
their effects cannot be determined with certainty, actual results and outcomes
may differ materially from our estimates, judgments and assumptions.



Management believes that the following accounting estimates are the most
critical to aid in fully understanding and evaluating our reported financial
results, and they require management's most difficult subjective or complex
judgments, resulting from the need to make estimates about the effect of matters
that are inherently uncertain. The following narrative describes these critical
accounting estimates, judgments and assumptions and the effect if actual results
differ from these assumptions.



Revenue Recognition



We enter into supply, license and collaboration arrangements with pharmaceutical
and biotechnology partners, some of which include royalty agreements based on
potential net sales of approved commercial pharmaceutical products.







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We recognize revenue in accordance with Accounting Standards Codification
("ASC") Topic 606, Revenue from Contracts with Customers ("ASC 606"). This
standard applies to all contracts with customers, except for contracts that are
within the scope of other standards, such as leases, insurance, collaboration
arrangements and financial instruments. Under ASC 606, an entity recognizes
revenue when its customer obtains control of promised goods or services, in an
amount that reflects the consideration which the entity expects to receive in
exchange for those goods or services. To determine revenue recognition for
arrangements that an entity determines are within the scope of ASC 606, the
entity performs the following five steps: (i) identify the contract(s) with a
customer; (ii) identify the performance obligations in the contract; (iii)
determine the transaction price; (iv) allocate the transaction price to the
performance obligations in the contract; and (v) recognize revenue at a point in
time, or over time, as it satisfies a performance obligation. We only apply the
five-step model to contracts when it is probable that it will collect the
consideration it is entitled to in exchange for the goods or services it
transfers to the customer. At contract inception, once the contract is
determined to be within the scope of ASC 606, we assess the goods or services
promised within each contract, determine those that are performance obligations,
and assess whether each promised good or service is distinct. We then recognize
as revenue the amount of the transaction price that is allocated to the
respective performance obligation when (or as) the performance obligation is
satisfied.



As part of the accounting for these arrangements, we must use significant
judgment to determine: a) the number of performance obligations based on the
determination under step (ii) above; b) the transaction price under step (iii)
above; and c) the stand-alone selling price for each performance obligation
identified in the contract for the allocation of transaction price in step (iv)
above. We use judgment to determine whether milestones or other variable
consideration should be included in the transaction price as described further
below. The transaction price is allocated to each performance obligation on a
relative stand-alone selling price basis, for which we recognize revenue as or
when the performance obligations under the contract are satisfied. In developing
the stand-alone price for a performance obligation, we consider applicable
market conditions and relevant entity-specific factors, including factors that
were contemplated in negotiating the agreement with the customer and estimated
costs. We validate the stand-alone selling price for performance obligations by
evaluating whether changes in the key assumptions used to determine the
stand-alone selling prices will have a significant effect on the allocation of
transaction price between multiple performance obligations. We recognize a
contract asset or liability for the difference between our performance (i.e.,
the goods or services transferred to the customer) and the customer's
performance (i.e., the consideration paid by, and unconditionally due from,

the
customer).



The terms of our license agreements may include delivery of an IP license to a
collaboration partner. We may be compensated under license arrangements through
a combination of non-refundable upfront receipts, development and regulatory
objective receipts and royalty receipts on future product sales by partners. We
anticipate recognizing non-refundable upfront license payments and development
and regulatory milestone payments received by us in license and collaboration
arrangements that include future obligations, such as supply obligations,
ratably over our expected performance period under each respective arrangement.
We make our best estimate of the period over which we expect to fulfill our
performance obligations, which may include technology transfer assistance,
research activities, clinical development activities, and manufacturing
activities from development through the commercialization of the product. Given
the uncertainties of these collaboration arrangements, significant judgment is
required to determine the duration of the performance period.



When we enter into an arrangement to sublicense some of our patents, we will
consider the performance obligations to determine if there is a single element
or multiple elements to the arrangement as we determine the proper method and
timing of revenue recognition. We consider the terms of the license or
sublicense for such elements as price adjustments or refund clauses in addition
to any performance obligations for us to provide such as services, patent
defense costs, technology support, marketing or sales assistance or any other
elements to the arrangement that could constitute an additional deliverable to
it that could change the timing of the revenue recognition. Non-refundable
upfront license and sublicense fees received, whereby continued performance or
future obligations are considered inconsequential or perfunctory to the relevant
licensed technology, are recognized as revenue upon delivery of the technology.



We expect to recognize royalty revenue in the period of sale, based on the
underlying contract terms, provided that the reported sales are reliably
measurable, we have no remaining performance obligations, and all other revenue
recognition criteria are met. We anticipate reimbursements for research and
development services completed by us related to the collaboration agreements to
be recognized in operations as revenue on a gross basis. Our license and
collaboration agreements with certain collaboration partners could also provide
for future milestone receipts to us based solely upon the performance of the
respective collaboration partner in consideration of deadline extensions or upon
the achievement of specified sales volumes of approved drugs. For such receipts,
we expect to recognize the receipts as revenue when earned under the applicable
contract terms on a performance basis or ratably over the term of the agreement.
These receipts may also be recognized as revenue when continued performance or
future obligations by us are considered inconsequential or perfunctory.







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Research and Development Expenses





Research and development expenses consist of expenses incurred in performing
research and development activities, including compensation and benefits,
facilities expenses, overhead expenses, pre-clinical development, clinical trial
and related clinical manufacturing expenses, fees paid to contract research
organizations ("CROs") and contract manufacturing organizations ("CMOs") and
other outside expenses. We expense research and development costs as incurred.
We expense upfront, non-refundable payments made for research and development
services as obligations are incurred. The value ascribed to intangible assets
acquired but which have not met capitalization criteria is expensed as research
and development at the time of acquisition. Upfront payments under license
agreements are expensed upon receipt of the license. Milestone payments under
license agreements are accrued, with a corresponding expense being recognized,
in the period in which the milestone is determined to be probable of achievement
and the related amount is reasonably estimable.



We are required to estimate accrued research and development expenses at each
reporting period. This process involves reviewing open contracts and purchase
orders, communicating with our personnel to identify services that have been
performed on our behalf and estimating the level of service performed and the
associated cost incurred for the service when we have not yet been invoiced or
otherwise notified of actual costs. The majority of our service providers
invoice us in arrears for services performed, on a pre-determined schedule or
when contractual milestones are met. However, some require advanced payments. We
make estimates of accrued expenses as of each balance sheet date in the
financial statements based on facts and circumstances known at that time. We
periodically confirm the accuracy of the estimates with the service providers
and make adjustments, if necessary. Examples of estimated accrued research and
development expenses include fees paid to:



· Collaborative partners performing research and development and pre-clinical

activities;

· Program managers in connection with overall program management of clinical


    trials;
  · CMOs in connection with cGMP manufacturing;
  · CROs in connection with clinical trials; and
  · Investigative sites in connection with clinical trials.




We base our expenses related to research and development, pre-clinical
activities and clinical trials on our estimates of the services received and
efforts expended pursuant to quotes and contracts with multiple research
institutions, CMOs and CROs that conduct and manage clinical trials on our
behalf. The financial terms of these agreements are subject to negotiation, vary
from contract to contract and may result in uneven payment flows. There may be
instances in which payments made to vendors will exceed the level of services
provided and result in a prepayment of the expense. In accruing service fees, we
estimate the time period over which services will be performed and the level of
effort to be expended in each period. If the actual timing of the performance of
services or the level of effort varies from the estimate, we adjust the accrual
or prepaid accordingly. Although we do not expect our estimates to be materially
different from amounts actually incurred, our understanding of the status and
timing of services performed relative to the actual status and timing of
services performed may vary and may result in reporting amounts that are too
high or too low in any particular period. To date, there have not been any
material adjustments to our prior estimates of accrued research and development
expenses.



Share-based Expense



Share-based expense includes grants of options and restricted stock units
("RSUs") to employees and non-employees to purchase shares of our common stock,
Joint Share Ownership Plan awards to employees and agreements to issue common
stock in exchange for services provided by non-employees.







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Share-based expense is based on the estimated fair value of the option or
calculated using the Black-Scholes option pricing model. Determining the
appropriate fair value model and related assumptions requires judgment,
including estimating share price volatility and expected terms of the awards.
The expected volatility rates are estimated based on the historical volatility
of the Company. To the extent Company data is not available for the full
expected term of the awards, we use a weighted average of our historical
volatility and of a peer group of comparable publicly traded companies over the
expected term of the option. The expected term represents the time that options
are expected to be outstanding. We account for forfeitures as they occur and not
at the time of grant. We have not paid dividends and do not anticipate paying
cash dividends in the foreseeable future and, accordingly, we use an expected
dividend yield of zero. The risk-free interest rate is based on the rate of U.S.
Treasury securities with maturities consistent with the estimated expected term
of the awards. Upon exercise, stock options are redeemed for newly issued shares
of our common stock. RSUs are redeemed for newly issued shares of our common
stock as the vesting and settlement provisions of the grant are met.



For employee options that vest based solely on service conditions, the fair
value measurement date is generally on the date of grant and the related
compensation expense is recognized on a straight-line basis over the requisite
vesting period of the awards. For non-employee options issued in exchange for
goods or services consumed in the Company's operations, the fair value
measurement date is the earlier of the date the performance of services is
complete or the date the performance commitment has been reached. We generally
determine that the fair value of the stock options is more reliably measurable
than the fair value of the services received. Compensation expense related to
stock options granted to non-employees is recognized on a straight-line basis
over requisite vesting periods of the awards.



Warrants



In connection with certain financing, consulting and collaboration arrangements,
we issued warrants to purchase shares of our common stock. The outstanding
warrants are standalone instruments that are not puttable or mandatorily
redeemable by the holder and are classified as equity awards. We measure the
fair value of the awards using the Black-Scholes option pricing model as of the
measurement date. Warrants issued to collaboration partners in conjunction with
the issuance of common stock are initially recorded at fair value as a reduction
in additional paid-in capital of the common stock issued.



All other warrants are recorded at fair value as expense on a straight-line
basis over the requisite service period or at the date of issuance if there is
not a service period or if service has already been rendered. For warrants that
contain vesting triggers based on the achievement of certain objectives, we
apply judgment to estimate the probability and timing of the achievement of
those objectives. These estimates involve inherent uncertainties, and as a
result, if the probability or timing of the achievement of those objectives
change, expense related warrants could be materially different in the future.
For warrants issued in connection with financing arrangements we allocate the
proceeds based on the relative fair value of the award and other instrument(s).



Indefinite-lived Intangible Assets


Assets acquired and liabilities assumed in business combinations, licensing and
other transactions are generally recognized at the date of acquisition at their
respective fair values. At acquisition, we generally determine the fair value of
intangible assets, including in-process research and development ("IPR&D"),
using the "income method." Acquired IPR&D intangible assets are considered
indefinite-lived intangible assets until completion or abandonment of the
associated research and development efforts. Substantial additional research and
development may be required before the Company's IPR&D reaches technological
feasibility. Upon completion of the IPR&D project, the IPR&D assets will be
amortized over their estimated useful lives.







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Indefinite lived intangibles are not amortized but are reviewed for impairment
at least annually or when events or changes in the business environment indicate
it is more likely than not that the carrying value may be impaired. Our annual
assessment may consist of a qualitative or quantitative analysis to determine if
it is more likely than not that its fair value exceeds the carrying value. When
performing the qualitative method, we determine whether the existence of events
or circumstances leads us to determine that it is more likely than not (that is,
a likelihood of more than 50%) that indefinite lived intangibles are impaired.
If we choose to first assess qualitative factors and it is determined that it is
not more likely than not that intangible assets are impaired, then we are not
required to take further action to test for impairment. We also have the option
to bypass the qualitative assessment and perform only the quantitative
impairment test, which we may choose to perform in some periods but not in
others. As the option to perform the qualitative assessment is not a permanent
election, we reassess this option during each annual impairment review. An
impairment loss, if any, is measured as the excess of the carrying value of the
intangible asset over its fair value.



Intangible assets are highly vulnerable to impairment charges, particularly
newly acquired assets for IPR&D. Considering the high risk nature of research
and development and the industry's success rate of bringing developmental
compounds to market, IPR&D impairment charges are likely to occur in future
periods. Estimating the fair value of IPR&D for potential impairment is highly
sensitive to changes in projections and assumptions and changes in assumptions
could potentially lead to impairment.



We believe our estimates and assumptions are reasonable and otherwise consistent
with assumptions that market participants would use in their estimates of fair
value. However, if future results are not consistent with our estimates and
assumptions, then we may be exposed to an impairment charge, which could be
material. Use of different estimates and judgments could yield materially
different results in our analysis and could result in materially different

asset
values or expense.


Effects of the COVID-19 Pandemic





During March 2020, a global pandemic was declared by the World Health
Organization related to the rapidly growing outbreak of a novel strain of
coronavirus, or COVID-19. The pandemic has significantly affected economic
conditions in the U.S., accelerating during the first half of March 2020 and
continuing throughout 2021 and into 2022, as federal, state and local
governments reacted to the public health crisis with mitigation measures,
creating significant uncertainties in the U.S. economy. We continue to evaluate
the effects of the COVID-19 pandemic on our business, and while there has been
no significant impact to our operations to date despite social distancing and
other measures taken in response to the pandemic, the ultimate impact of the
COVID-19 pandemic on our results of operations and financial condition is
dependent on future developments, including the duration of the pandemic and the
related extent of its severity, the pace and rate at which vaccines are
administered, and the continued emergence of new strains of COVID-19, such as
the Delta and Omicron variants and any subvariants, as well as its impact on
macroeconomic conditions, which are uncertain and cannot be predicted at this
time. If the global response to contain the COVID-19 pandemic escalates further
or is unsuccessful, or if governmental decisions to ease pandemic related
restrictions are ineffective, premature or counterproductive, we could
experience a material adverse effect on our business, financial condition,
results of operations and cash flows.



Impact of the Conflict in Ukraine on Our Operations

The short and long-term implications of Russia's invasion of Ukraine are difficult to predict at this time. The imposition of sanctions and counter sanctions may have an adverse effect on the economic markets generally and could impact our business, financial condition, and results of operations.









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Results of Operations



The table below sets forth the comparison of our historical results of
operations for the year ended December 31, 2022 to the year ended December 31,
2021.



                                                                        Increase        Percentage
Description                              2022             2021         (Decrease)         Change
Revenue:
Royalty revenue                      $  1,706,925     $  1,160,692     $   546,233            47.1%
Operating costs and expenses:
Research and development               (4,770,834 )     (3,163,485 )     1,607,349            50.8%
General and administrative             (3,653,999 )     (3,743,972 )       (89,973 )           (2.4 )%
Total operating costs and expenses     (8,424,833 )     (6,907,457 )     1,517,376            22.0%
Loss from operations                   (6,717,908 )     (5,746,765 )       971,143            16.9%
Other income (expense):
Other income (expense)                     (1,597 )          1,119           2,716           242.7%
Interest income, net                      167,152          100,467          66,685            66.4%
Net loss                             $ (6,552,353 )   $ (5,645,179 )   $   907,174            16.1%




Revenue


Revenue for the year ended December 31, 2022 increased by $0.5 million, or 47.1%, to $1.7 million from approximately $1.2 million for the year ended December 31, 2021. The increase represents an increase in royalty revenue related to our sublicense agreement with Takeda as compared to the same period in 2021.

Research and Development Expense





Overall, R&D expenses for the year ended December 31, 2022 increased by $1.6
million, or 50.8% to $4.8 million from $3.2 million in the comparable period in
2021 primarily due to IPR&D expense of $1.8 million. During the year ended
December 31, 2022, the Company expensed $1.8 million of IPR&D associated with
the Company's licensing of the DNase platform. There was no similar expense in
2021 The table below sets forth the R&D costs incurred by us, by category of
expense, for the year ended December 31, 2022 and 2021:



                                                         Year ended December 31,
                Category of Expense                        2022            2021
IPR&D expense                                          $  1,793,750     $         -
Outside services and contract research organizations      2,314,513       2,497,190
Salaries and wages                                          435,564         457,313
Share-based expense                                          86,305          68,208
Other                                                       140,702         140,774
Total research and development expense                 $  4,770,834     $ 3,163,485








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Excluding the $1.8 million of IPR&D expense from total R&D expense of $4.8
million, R&D expenses decreased approximately $0.2 million, or 5.9% to $3.0
million for the year ended December 31, 2022, from $3.2 million for the year
ended December 31, 2021. The decrease in outside services and contract research
organizations expense was primarily due to decreased spending in connection with
our XCART technology platform, which was substantially offset by costs related
to the licensing and our initial development efforts related to our DNase
platform. We licensed the DNase platform in April 2022 and expect to direct our
efforts and resources on the development of this newly acquired technology. As a
result, we have suspended development of our XCART technology platform.



General and Administrative Expense





General and administrative expenses for the year ended December 31, 2022 was
$3.7 million, decreasing by approximately $0.1 million, or 2.4%, compared to the
same period in the prior year. The decrease was primarily due to a decrease in
consulting and legal costs associated with our intellectual property portfolio
substantially offset by an increase in legal costs related to the licensing of
the DNase oncology platform from CLS during the year ended December 31, 2022
compared to the same period in 2021.



Other Income (Expense)



Other expense was approximately $1,600 for the year ended December 31, 2022
compared to other income of approximately $1,100 for the same period in 2021.
This increase in other expense was primarily related to unfavorable changes in
foreign currency exchange rates during the year ended December 31, 2022 as
compared to the same period in 2021.



Interest Income, net



Interest income, net increased to approximately $0.2 million during the year
ended December 31, 2022 as compared to approximately $0.1 million for the same
period in the prior year. This increase is primarily due to an increase in
interest income due to higher interest rates on invested funds during the year
ended December 31, 2022 compared to the same period in 2021. This increase was
partially offset by a decrease in interest income on the Pharmsynthez Loan.

Liquidity and Capital Resources





We incurred a net loss of approximately $6.6 million for the year ended December
31, 2022. We had an accumulated deficit of approximately $189.1 million at
December 31, 2022, as compared to an accumulated deficit of approximately $182.5
million at December 31, 2021. Working capital was approximately $12.6 million at
December 31, 2022, and $17.3 million at December 31, 2021, respectively. During
the year ended December 31, 2022, our working capital decreased by $4.7 million
primarily due to our net loss for the year ended December 31, 2022 and cash of
$0.5 million used to obtain a license to the DNase oncology platform.



Our principal source of liquidity consists of cash. At December 31, 2022, we had
approximately $13.1 million in cash and $1.1 million in current liabilities. At
December 31, 2021, we had approximately $18.2 million in cash and $1.4 million
in current liabilities.







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We evaluate whether there are conditions or events, considered in the aggregate
that raise substantial doubt about our ability to continue as a going concern
within one year after the date that the financial statements are issued. We have
incurred substantial losses since our inception, and we expect to continue to
incur operating losses in the near-term. These factors raise substantial doubt
about our ability to continue as a going concern. We believe that we have access
to capital resources through possible public or private equity offerings, debt
financings, corporate collaborations, related party funding, or other means to
continue as a going concern. We believe that our existing resources will be
adequate to fund our operations for a period of at least twelve months from the
date of these financial statements. However, we anticipate we may need
additional capital in the long-term to pursue our business initiatives. The
terms, timing and extent of any future financing will depend upon several
factors, including the achievement of progress in our clinical development
programs, our ability to identify and enter into licensing or other strategic
arrangements, our continued listing on the Nasdaq Stock Market ("Nasdaq"), and
factors related to financial, economic, geo-political, industry and market
conditions, many of which are beyond our control. The capital markets for the
biotech industry can be highly volatile, which make the terms, timing and extent
of any future financing uncertain. On June 3, 2022, we received a written
notification (the "Notice") from the Listing Qualifications Department of Nasdaq
notifying us that the closing bid price for our common stock had been below
$1.00 for 30 consecutive business days and that we therefore were not in
compliance with the minimum bid price requirement for continued inclusion on the
Nasdaq Capital Market under Nasdaq Listing Rule 5550(a)(2) (the "Bid Price
Requirement"). The Notice has no immediate effect on the listing of our common
stock on the Nasdaq Capital Market. Under the Nasdaq Listing Rules, we had a
period of 180 calendar days from the date of the Notice to regain compliance
with the Bid Price Requirement. Accordingly, we had until November 30, 2022 to
regain compliance with the Bid Price Requirement and were eligible for an
additional 180 calendar day compliance period if certain other criteria were
met. On December 1, 2022, we received a letter from Nasdaq informing us that
although our common stock had not regained compliance with the minimum $1.00 bid
price per share requirement, Nasdaq had determined that we were eligible for an
additional 180 calendar day period, or until May 29, 2023, to regain compliance.
Nasdaq's determination was based on the Company meeting the continued listing
requirement for market value of publicly held shares and all other applicable
requirements for initial listing on the Nasdaq Capital Market with the exception
of the bid price requirement, and our written notice of our intention to cure
the deficiency during the second compliance period by effecting a reverse stock
split, if necessary.



On March 10, 2023, SVB was closed by the California Department of Financial
Protection and Innovation, which appointed the FDIC as receiver. We maintained
our cash primarily with SVB. On March 12, 2023, the U.S. Treasury, Federal
Reserve and FDIC rolled out emergency measures to fully protect all depositors
of SVB and, on March 13, 2023, we had full access to our cash on deposit with
SVB. As a result, we do not anticipate any losses with respect to such balances.



Cash Flows from Operating Activities





Cash flows used in operating activities for the year ended December 31, 2022
totaled approximately $4.6 million, which was primarily due to our net loss for
the period, partially offset by non-cash charges associated with acquired IPR&D
and share-based expense. In addition, current liabilities decreased during the
year ended December 31, 2022. Cash flows used in operating activities for the
year ended December 31, 2021 totaled approximately $4.7 million, which was
primarily due to our net loss for the period, partially offset by non-cash
charges associated with share-based expense.



Cash Flows from Investing Activities





Cash flows used in investing activities for the year ended December 31, 2022
totaled $500,000, which represented cash paid to license the DNase oncology
platform. There were no cash flows from investing activities for the year ended
December 31, 2021.


Cash Flow from Financing Activities





There were no cash flows from financing activities for the year ended December
31, 2022. Cash flows from financing activities for the year ended December 31,
2021 totaled approximately $11.5 million representing net proceeds from our
private placement in July 2021.







  65






Contractual Obligations



Contractual obligations represent future cash commitments and liabilities under
agreements with third-parties and exclude contingent liabilities for which we
cannot reasonably predict future payment. Our contractual obligations result
from property leases for office space. Although we do have obligations for CMO
services, the table below excludes potential payments we may be required to make
under our agreements with CMOs because timing of payments and actual amounts
paid under those agreements may be different depending on the timing of receipt
of goods or services or changes to agreed-upon terms or amounts for some
obligations, and those agreements are cancelable upon written notice by the
Company and therefore, not long-term liabilities. The contracts may also contain
variable costs that are hard to predict as they are based on such things as
patients enrolled and clinical trial sites, which can vary and, therefore, are
also not included in the table below. Additionally, the expected timing of
payment of the obligations presented below is estimated based on current
information.



The following tables represent our contractual obligations as of December 31,
2022, aggregated by type:



                                      Payments Due by Period
                                      As of December 31, 2022
                                   Less                                 More
                                   than         1-3         3-5         than
                     Total        1 year       years       years       5 years
Lease obligations   $ 28,524     $ 28,524     $     -     $     -     $       -
Total               $ 28,524     $ 28,524     $     -     $     -     $       -




Recent Accounting Standards


Refer to Note 3, Summary of Significant Accounting Policies, of the accompanying financial statements set forth in Item 8.

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