On February 8, 2023, Shaan Gandhi, MD, PhD, MBA, notified Vigil Neuroscience, Inc. (“ Vigil”) of his resignation as a member of Vigil's board of directors (the “ Board”), effective as of February 10, 2023, where he serves as a Class I director and member of the Audit and Compensation Committees. Dr. Gandhi's resignation is because he has accepted employment with a third party, the terms of which do not permit service as a board member of any company. Dr. Gandhi's resignation did not result from any disagreement with the Company on any matter relating to the Company's operations, policies, or practices.

The Company thanks Dr. Gandhi for his substantial contributions as a founding Board member and wishes him well in his future endeavors.