On December 27, 2022, the President and Chief Strategy Officer of UpHealth, Inc., Dr. Ramesh Balakrishnan, informed the Company's Board of Directors that he is resigning from his role as President and Chief Strategy Officer of the Company effective December 30, 2022. There are no changes to the severance that Dr. Balakrishnan is entitled to receive upon his resignation pursuant to his employment agreement with the Company, as amended, as previously disclosed by the Company. Following his resignation, Dr. Balakrishnan is available to advise the Company's Chief Executive Officer as appropriate, although the Company and Dr. Balakrishnan have no agreement with terms for such advisory role.