The research program will be led by
'We are proud and excited to be establishing this partnership with NCI to deepen our understanding of our lead compounds, NOX-A12 and NOX-E36, in brain tumors. By using three different brain cancer models with very distinct immunological characteristics, this research will greatly improve the understanding of the effect of our compounds on the tumor biology. The work is also expected to deliver insights into whether and how our CXCL12 and CCL2 antagonist can be synergistic with other approaches in altering the brain tumor microenvironment, with the aim of facilitating a relevant anti-tumor immune reaction,' said
NOX-A12 is being investigated in the Phase 1/2 GLORIA dose-escalation study in brain cancer (glioblastoma) patients, top-line data from which were presented at the 2022
Contact:
Chief Executive Officer
Tel: +49 (0) 30 726247 0
E: amangasarian@noxxon.com
About NOXXON
NOXXON's oncology-focused pipeline acts on the tumor microenvironment (TME) and the cancer immunity cycle by breaking the tumor protection barrier and blocking tumor repair. By neutralizing chemokines in the TME, NOXXON's approach works in combination with other forms of treatment to weaken tumor defenses against the immune system and enable greater therapeutic impact. NOXXON's lead program NOX-A12 has delivered final top-line data from a Keytruda combination trial in metastatic colorectal and pancreatic cancer patients published at the ESMO conference in
About the GLORIA Study
GLORIA (NCT04121455) is NOXXON's dose-escalation, phase 1/2 study of NOX-A12 in combination with irradiation in first-line partially resected or unresected glioblastoma (brain cancer) patients with unmethylated MGMT promoter (resistant to standard chemotherapy). GLORIA further evaluates safety and efficacy of NOX-A12 three additional arms combining NOX-A12 with: A. radiotherapy in patients with complete tumor resection; B. radiotherapy and bevacizumab; and C. radiotherapy and pembrolizumab.
About the OPTIMUS Study
OPTIMUS (NCT04901741) is NOXXON's open-label two-arm phase 2 study of NOX-A12 combined with pembrolizumab and nanoliposomal irinotecan/5-FU/leucovorin or gemcitabine/nab-paclitaxel in microsatellite-stable metastatic pancreatic cancer patients.
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