As of September 14, 2021, Skye Bioscience, Inc. terminated its engagement with RoseRyan, Inc, a professional services firm which provided accounting and financial advisory services to the Company. As such, Richard Janney, the company's Principal Accounting Officer engaged through RoseRyan, has tendered his resignation with the Company. Mr. Janney's resignation will be effective September 14, 2021, and is unrelated to any disagreement with the Company or its Board of Directors, or any matter relating to its operations, policies or practices. Punit Dhillon, Chief Executive Officer, President, Secretary, Chair of the Board, and Director of the Company, will serve as the principal accounting officer until a successor is appointed.