Director Share Dealings September 30, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announces that today Ordinary Shares ("Shares") and American Depository Shares ("ADSs") of the Company, as set out below, have been acquired for the Non-Executive Directors, being the part of their total fees that are paid in shares for the period of service from July 1 to September 30, 2014. Type of Security(1) Number of Shares/ADSs Dominic Blakemore Shares 98 William Burns Shares 99 Dr. Steven Gillis ADSs 32 Dr. David Ginsburg ADSs 30 David Kappler Shares 104 Susan Kilsby ADSs 100 Anne Minto Shares 104 David Stout ADSs 32 (1) One ADS is equal to three Shares The Shares and ADSs were acquired on the London Stock Exchange and NASDAQ respectively at prices of £53.45 per Share and $259.9747 per ADS. This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a) of the Disclosure and Transparency Rules. Tony Guthrie Deputy Company Secretary For further information please contact: Investor Relations Jeff Poulton jpoulton@shire.com +1 781 482 0945 Sarah Elton-Farr seltonfarr@shire.com +44 1256 894157 Media Stephanie Fagan sfagan@shire.com +1 781 482 0460 Gwen Fisher gfisher@shire.com +1 484 595 9836 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialty medicines to meet significant unmet patient needs. We focus on providing treatments in Neuroscience, Rare Diseases, Gastrointestinal, and Internal Medicine and we are developing treatments for symptomatic conditions treated by specialist physicians in other targeted therapeutic areas, such as Ophthalmology. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com
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