On October 31, 2022, William F. Ciambrone informed Sarepta Therapeutics, Inc. (the Company) of his resignation from his position as the Company's Executive Vice President, Technical Operations, effective as of December 31, 2022. On October 31, 2022, the Board appointed Bilal Arif, the Company's Senior Vice President, Strategy and Operations, as the Company's Chief Technical Operations Officer, effective as of December 31, 2022 and upon Mr. Ciambrone's retirement.