Recursion announced its partnership with Enamine to generate enriched screening libraries with insights from Recursion's protein-ligand interaction predictions spanning across Enamine's massive library of 36 billion compounds. To begin the partnership, Enamine and Recursion will mutually agree upon up to 100 biological targets around which they will build screening libraries. From there, Recursion will utilize MatchMaker's predicted protein-ligand interactions for Enamine REAL Space containing 36B compounds to design compound libraries enriched for molecules that are likely to bind to biological targets.

Enamine may offer the resulting libraries to customers for purchase and will co-brand any libraries under both the Enamine and MatchMaker trademarks. Recursion believes that these new libraries will be of interest to customers given the additional predictive insights via MatchMaker. The tool employs machine learning to evaluate the suitability of small molecules for specific protein binding pockets and is more scalable than traditional docking and physics-based interaction simulations.

Similar to Recursion's Phenomics platform, MatchMaker's scalability affords a comprehensive view of biochemistry; it can predict binding activity for large quantities of molecules across the proteome. The predicted data can guide the selection of wet-lab experiments, helping to expedite progress across a diverse range of targets and chemical areas, and can act as a preliminary screening tool for more computationally intensive precision modeling techniques. As part of the agreement, Recursion will receive a significant number of unique REAL compounds of Recursion's choosing to augment its internal compound library, at no cost.

Furthermore, Recursion will receive preferential pricing on any enriched screening libraries made available to Enamine customers as part of the collaboration.