On November 8, 2022, the Company received the resignation of Maxine Gowen from her role as Interim Executive Chairwoman of the Board of Directors of the Company (the “Board”), effective as of November 10, 2022 (the “Effective Date”). On the Effective Date, Dr. Gowen will resume her status as an independent director and will remain Chairwoman of the Board. Dr. Gowen will also resume her role as a member of the Board's Compensation Committee and as a member and the Chairwoman of the Nominating and Corporate Governance Committee.