Poster Presentation Details:
Title: Initial findings from first-in-human phase 1a/b study of NX-5948, a selective Bruton’s tyrosine kinase (BTK) degrader, in patients with relapsed/refractory B cell malignancies
Authors:
Session
Prospective Therapeutic Trials: Poster III
Session Date and Time:
Publication Number: 4473
Title: A first-in-human phase 1 trial of NX-2127, a first-in-class Bruton's Tyrosine Kinase (BTK) dual-targeted protein degrader with immunomodulatory activity, in patients with relapsed/refractory B cell malignancies
Authors:
Session
Prospective Therapeutic Trials: Poster III
Session Date and Time:
Publication Number: 4463
Title: A First-in-Human Phase 1 Trial of NX-1607, a First-in-Class Oral CBL-B Inhibitor, in Patients with Advanced Malignancies Including DLBCL
Authors:
Session
Prospective Therapeutic Trials: Poster III
Session Date and Time:
Publication Number: 3093
About NX-2127
NX-2127 is a novel bifunctional molecule that degrades BTK and cereblon neosubstrates Ikaros (IKZF1) and
About NX-5948
NX-5948 is an investigational, orally bioavailable, small molecule degrader of BTK that, unlike NX-2127, has been designed to lack cereblon immunomodulatory activity. NX-5948 is currently being evaluated in a Phase 1 clinical trial in patients with relapsed or refractory B cell malignancies. Additional information on the ongoing clinical trial can be accessed at clinicaltrials.gov (NCT05131022).
About NX-1607
NX-1607 is an orally bioavailable inhibitor of Casitas B-lineage lymphoma proto-oncogene B (CBL-B) for immuno-oncology indications including a range of solid tumor types. NX-1607 acts on T cells, NK cells, and dendritic cells to enhance anti-tumor immunity, and has demonstrated single-agent anti-tumor activity in multiple tumor models. NX-1607 is currently being evaluated in a Phase 1 clinical trial in adults with a variety of oncology indications. Additional information on the ongoing clinical trial can be accessed at www.clinicaltrials.gov (NCT05107674).
About
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