The agreement between van den Boom & Associates LLC and MediciNova Inc. through which Esther van den Boom served as Chief Financial Officer expired without renewal on March 31, 2016. Concurrently with the expiration, Ms. van den Boom no longer serves as the Company's principal financial officer and principal accounting officer. Effective March 31, 2016, the Company appointed Ryan Selhorn, age 34, as Chief Financial Officer of the Company.

He will also serve as the Company's principal financial officer and principal accounting officer. Mr. Selhorn joined Signature Analytics as the Vice President Operations in July 2013 after spending 10 years with Grant Thornton LLP, most recently as a Senior Manager in the audit practice and then in the national Mergers and Acquisitions Group. He has experience working with both public and private companies in many industries including life sciences, biotech, and medical devices.