Kindred Biosciences, Inc. unveiled positive results in a new long-acting interleukin (IL)-31 antibody program (KIND-039) that integrates the company's novel half-life extension technology. Results from the pharmacokinetic study of the molecule demonstrate that the fully caninized, high-affinity antibody has up to a three-fold longer half-life compared to tirnovetmab. This extended half-life is expected to allow for up to three-fold longer interval between dosing. The company's half-life extension technology is designed to improve therapeutic performance in a multitude of ways. The reduced dosing frequency and/or amount of dosing can lead to improved patient convenience and compliance. The technology can also significantly reduce the cost of goods and enhance profitability and market positioning. In addition, higher drug concentration using the same dose and dosing interval as the parent antibody can result in extended and more uniform therapeutic exposure and potentially improve efficacy and safety. The company plans to leverage this platform technology for long-lasting therapeutics to develop to best-in-class products across multiple indications. The new long-acting IL-31 program is expected to be complementary to the company's tirnovetmab monoclonal antibody program targeting IL-31, for which a pivotal study was initiated in December, 2020. The company's market research shows that longer intervals between dosing is a key determinant of commercial success, but given the large size of the market and the heterogeneous nature of canine dermatitis, both products are expected to be well-received by veterinarians and owners. KindredBio first announced its half-life extension technology for canine antibodies in January 2020.