The molecular properties of nipocalimab in the treatment of generalized myasthenia gravis will be presented at the 2024 annual meeting of the American Academy of Neurology.
Analysis of clinical and non-clinical studies confirms the potential of the investigational treatment for a rapid, profound and long-lasting decrease in immunoglobulin G (IgG) says the group.
' These data show that nipocalimab is a potential best-in-class blocker of FcRn, with unique features including high binding affinity and specificity for the immunoglobulin G (IgG) binding site of FcRn '.
"These new data provide further evidence of nipocalimab's potential to deliver optimized therapeutic outcomes for autoantibody-induced neurological diseases such as von Willebrand disease', said Sindhu Ramchandren, M.D., Clinical Development Leader, Neuroscience, Johnson & Johnson Innovative Medicine.
"There remains a significant unmet need for more effective therapies capable of providing sustained disease control in the case of gMG."
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Johnson & Johnson is one of the world's leading producers of healthcare products. Net sales break down by family of products as follows:
- pharmaceutical products (55.4%): drugs intended for the treatment of cardiovascular diseases, oncological diseases, gastro-intestinal illnesses, infectious, immunological, neurological, dermatological diseases, etc.;
- medical products and equipment (28.9%): diagnostic systems, orthopedic and gynecological equipment, surgical materials, etc. for use by healthcare professionals;
- consumer health products (15.7%): OTC drugs (Tylenol, Sudafed, Benadryl, Zyrtec, Motrin, Nicorette and other brands), health and beauty products (Aveeno, Clean & Clear, Dr. CI:Labo, Neutrogena and OGX), baby care products (Johnson's and Aveeno Baby), oral care products (Listerine), feminine hygiene products (Stayfree and Carefree and o.b.), wound care products (Band-Aid and Neosporin) etc.
At the end of 2022, Johnson & Johnson has 89 manufacturing facilities located in the United States (28), North America (9), Europe (27), Africa and Asia/Pacific (25).
Net sales are distributed geographically as follows: the United States (51.2%), Europe (24.7%), Asia/Pacific and Africa (17.7%) and other (6.4%).