Inari Medical, Inc. announced that the first patient has been enrolled in DEFIANCE, a prospective randomized controlled trial (RCT) comparing the clinical outcomes of patients with iliofemoral deep vein thrombosis (DVT) treated with the ClotTriever System versus anticoagulation only. The trial is led by Principal Investigators: Dr. Xhorlina Marko, Interventional Radiologist at Beaumont Health; Dr. Steven Abramowitz, Chair of Vascular Surgery at MedStar Health; and Professor Stephen Black, MD, consultant vascular surgeon, Guy's and St. Thomas' Hospital, London.

The first DEFIANCE patient was enrolled by Dr. Abdullah Shaikh, Interventional Radiologist at Allegheny Health Network, Pittsburgh, PA.DEFIANCE will enroll 300 DVT patients at up to 60 centers worldwide. DEFIANCE is Inari's second RCT, enrolling in parallel to the PEERLESS pulmonary embolism trial.