Immatics Corporate Presentation
March 21, 2024
Delivering the Power of T cells to Cancer Patients
© Immatics. Not for further reproduction or distribution.
© Immatics. Not for further reproduction or distribution.
Forward-Looking Statement
This presentation ("Presentation") is provided by Immatics N.V. ("Immatics" or the "Company") for informational purposes only. The information contained herein does not purport to be all- inclusive and none of Immatics, any of its affiliates, any of its or their respective control persons, officers, directors, employees or representatives makes any representation or warranty, express or implied, as to the accuracy, completeness or reliability of the information contained in this Presentation.
Forward-Looking Statements. Certain statements in this presentation may be considered forward-looking statements. Forward-looking statements generally relate to future events or the Company's future financial or operating performance. For example, statements concerning timing of data read-outs for product candidates, the timing and outcome of clinical trials, the nature of clinical trials (including whether such clinical trials will be registration-enabling), the timing of IND or CTA filing for pre-clinical stage product candidates, estimated market opportunities of product candidates, the Company's focus on partnerships to advance its strategy, and other metrics are forward-looking statements. In some cases, you can identify forward-looking statements by terminology such as "may", "should", "expect", "plan", "target", "intend", "will", "estimate", "anticipate", "believe", "predict", "potential" or "continue", or the negatives of these terms or variations of them or similar terminology. Such forward-looking statements are subject to risks, uncertainties, and other factors which could cause actual results to differ materially from those expressed or implied by such forward looking statements. These forward-looking statements are based upon estimates and assumptions that, while considered reasonable, Immatics and its management, are inherently uncertain. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. Factors that may cause actual results to differ materially from current expectations include, but are not limited to, various factors beyond management's control including general economic conditions and other risks, uncertainties and factors set forth in the Company's Annual report on Form 20-F and other filings with the Securities and Exchange Commission (SEC). Nothing in this presentation should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved. You should not place undue reliance on forward-looking statements, which speak only as of the date they are made. The Company undertakes no duty to update these forward-looking statements.
No Offer or Solicitation. This communication is for informational purposes only and does not constitute, or form a part of, an offer to sell or the solicitation of an offer to sell or an offer to buy or the solicitation of an offer to buy any securities, and there shall be no sale of securities, in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction. No offer of securities shall be made except by means of a prospectus meeting the requirements of Section 10 of the Securities Act of 1933, as amended, or in an offering exempt from registration.
Certain information contained in this Presentation relates to or is based on studies, publications, surveys and the Company's own internal estimates and research. In addition, all of the market data included in this presentation involves a number of assumptions and limitations, and there can be no guarantee as to the accuracy or reliability of such assumptions. Finally, while the Company believes its internal research is reliable, such research has not been verified by any independent source. All the scientific and clinical data presented within this presentation are - by definition prior to completion of the clinical trial and a clinical study report - preliminary in nature and subject to further quality checks including customary source data verification.
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Building a Leading TCR Therapeutics Company
Two Clinical-Stage Modalities
Pipeline of TCR-T and TCR Bispecific product candidates in clinical & preclinical development
Clinical PoC for | Differentiated | Therapeutic |
Cell Therapy | Platforms | Opportunity |
Anti-tumor activity and | Unique technologies | Potential for addressing |
durability of response | to identify true | large patient populations |
across multiple solid | cancer targets | with high prevalence |
tumors in early TCR-T | and right TCRs | targets in solid tumors |
clinical development |
Intro | 3 |
Upcoming 2024 Catalysts for ACTengine® and TCER® Clinical Lead Assets
Projected Cash Runway into 2027 to Reach Multiple Value Inflections Points
ACTengine®
IMA203 / IMA203CD8 (PRAME)
-
Targeted registration-enabling randomized Phase 2/3 trial1 for ACTengine® IMA203 GEN1
in 2L+ melanoma in 2024 - Data updates for IMA203 GEN1 & IMA203CD8 GEN2 planned in 2H 2024
TCER® IMA401 (MAGEA4/8)
First clinical data update from dose escalation in ongoing Phase 1 trial planned in 2H 2024
TCER® IMA402 (PRAME)
First clinical data update from dose escalation in ongoing Phase 1/2 trial planned in 2H 2024
Initial focus indications: Ovarian cancer, uterine cancer, lung cancer, melanoma and others
Updates planned across the entire clinical portfolio throughout 2024
Intro | 1 This trial will be designed to support accelerated approval based on an interim readout and full approval based on overall survival. The high prevalence of PRAME (≥95%) in cutaneous melanoma may enable enrollment of patients without | 4 |
PRAME pre-testing and could remove the need to develop a companion diagnostic in this indication. The full trial design is currently being developed and is subject to further alignment with the FDA as part of the ongoing discussions. |
Our TCR-based Approaches Leverage the Full Target Space beyond the Cancer Cell Surface
Intro | 5 |
Two Distinct TCR-based Therapeutic Modalities in Clinical Development
Autologous TCR-T (ACTengine®) | TCR Bispecifics (TCER®) |
- Strong clinical activity in patients with high tumor burden1
- Single dose2
- Proprietary manufacturing process for enhanced potency of T cells
- Specialized medical centers
- Target requirements: stringent tumor selectivity, low, medium, high copy numbers
- Off-the-shelfbiologic for immediate treatment
- Repeat dosing
- All hospitals and out-patient, opportunity for larger patient reach
- Favorable commercial characteristics
- Target requirements: strong tumor association, medium to high copy numbers
Differentiated positioning of ACTengine® vs. TCER® based on patient population and medical need
Intro | 1 Interim data update from the ACTengine® IMA203/IMA203CD8 monotherapies (published November 08, 2023); | 6 |
2 Initial manufacturing may provide sufficient quantity for potential repeat dosing. |
Our Pipeline of TCR-based Adoptive Cell Therapies and Bispecifics
Modality | Product Candidate | Target | Preclinical | Phase 1a1 | Phase 1b1 | Phase 2 | Phase 3 |
ACTengine® IMA203 | PRAME | ||||||
Autologous ACT | ACTengine® IMA203CD8 | PRAME | |||||
ACTengine® IMA204 | COL6A3 | ||||||
Multiple programs | Undisclosed | ||||||
Allogeneic ACT | ACTallo® IMA30x | Undisclosed | 2 | ||||
γδ T cells | Multiple programs | Undisclosed | |||||
TCER® IMA401 | MAGEA4/8 | ||||||
Bispecifics | TCER® IMA402 | PRAME | |||||
TCER® IMA40x | Undisclosed | ||||||
Multiple programs3 | Undisclosed |
Intro | 1 Phase 1a: Dose escalation, Phase 1b: Dose expansion; 2 Immatics' proprietary ACTallo® platform utilizing Editas' CRISPR gene editing technology; | 7 |
3 mRNA-enabledin vivo expressed TCER® molecules | ||
Potential for Large Patient Populations across Multiple Solid Cancers
IMA203 / IMA402
PRAME
Uterine Carcinoma - 97% Uterine Carcinosarcoma - 100% Sarcoma Subtypes - up to 100% Cut. Melanoma ≥ 95%
Uveal Melanoma1 ≥ 91% Ovarian Carcinoma - 84% Squamous NSCLC - 68% TNBC - 63%
Small Cell Lung Cancer - 45% Kidney Carcinoma - up to 40% Cholangiocarcinoma - 33% HNSCC - 27%
Esophageal Carcinoma - 27% Breast Carcinoma- 26% Adeno NSCLC - 25%
HCC - 18%
Bladder Carcinoma - 18%
IMA401
MAGEA4/8
Squamous NSCLC - 52% Sarcoma Subtypes - up to 60% HNSCC - 36%
Bladder Carcinoma - 29% Uterine Carcinosarcoma - 29% Esophageal Carcinoma - 23% Ovarian Carcinoma - 23% Melanoma - 18%
IMA204
COL6A3 Exon 6
Pancreatic Carcinoma - 76%
Breast Carcinoma - 77%
Stomach Carcinoma - 67%
Sarcoma - 63%
Colorectal Carcinoma - 60%
Esophageal Carcinoma - 60%
Squamous NSCLC- 55%
Adeno NSCLC- 57%
HNSCC - 56%
Uterine Carcinosarcoma - 50%
Mesothelioma - 44%
Cholangiocarcinoma - 36%
Melanoma - 35%
Bladder Carcinoma - 34%
Ovarian Carcinoma - 31%
ACTengine® and TCER® targets demonstrate high prevalence in multiple solid cancers
Intro | Target prevalence for selected solid cancer indications are based on TCGA (for SCLC: in-house) RNAseq data combined with a proprietary mass spec-guided RNA expression threshold; | 8 |
1 Uveal melanoma target prevalence is based on IMADetect® qPCR testing of screening biopsies from clinical trial patients (n=33) |
Realizing the Full Multi-Cancer Opportunity of PRAME
ACTengine® IMA203 (TCR-T) and TCER® IMA402 (TCR Bispecific)
Indication
Uterine Carcinoma
Uterine Carcinosarcoma
Sarcoma Subtypes
Cut. Melanoma
Uveal Melanoma2
Ovarian Carcinoma
Squamous NSCLC
TNBC
Small Cell Lung Cancer
Kidney Carcinoma
Cholangiocarcinoma
HNSCC
Esophageal Carcinoma
Breast Carcinoma
Adeno NSCLC
HCC
Bladder Carcinoma
-
PRAME
positive patients1
97%
100%
up to 100% ≥95% ≥91% 84% 68% 63% 45%
up to 40% 33% 27% 27% 26% 25% 18% 18%
ACTengine® | Phase 1b dose |
IMA203 | expansion |
(TCR-T) | ongoing |
Cancer Cell | TCER® IMA402 |
Death | |
(TCR Bispecific) |
Dose escalation of Phase 1/2 trial ongoing
PRAME is one of the most promising and most prevalent, clinically validated solid tumor targets known to date
Leverage the full potential of targeting PRAME by continued
evaluation of the best suited therapeutic modality (ACTengine® vs. TCER® or both) for each cancer type
Intro | 1 PRAME target prevalence is based on TCGA (for SCLC: in-house) RNAseq data combined with a proprietary mass spec-guided RNA expression threshold; 2 Uveal melanoma target prevalence is based on IMADetect® qPCR testing of | 9 |
screening biopsies from clinical trial patients (n=33); NSCLC: Non-small cell lung cancer, TNBC: Triple-negative breast cancer, HNSCC: Head and neck squamous cell carcinoma; HCC: Hepatocellular carcinoma |
ACTengine® IMA203 - TCR-T Targeting PRAME
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Immatics NV published this content on 21 March 2024 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 21 March 2024 11:05:28 UTC.