ICON plc has unveiled Flex Advantage, a next-generation interactive response technology, or IRT, platform to enhance randomization and clinical supply management capabilities and support the execution of adaptive trials. Flex Advantage incorporates a host of new features that meet the demands of the most complex protocols. Flex Advantage contains a flexible randomization engine that can be adjusted mid-study or dynamically, which enables the execution of adaptive clinical trials and more traditional protocol changes.

Flex Advantage supports adaptive randomization trials efficiently, while maintaining trial data integrity throughout. Flex Advantage supports various randomization methods using easy to use plug-and-play modules, allowing for easy configuration to suit the needs of the trial. Flex Advantage enables emergency unblinding during the course of a trial and includes additional safeguards that prevent inappropriate sharing of blinded information.

Flex Advantage empowers study teams by providing a full complement of real time web reports that are available via a customizable dashboard. The system's ad hoc reporting capability enables users to quickly and easily create custom reports and also provides drill down functionality to enable users to interact with, and better understand, their study data. Flex Advantage is integrated with ICON products, such as ADDPLAN, Firecrest and ICONIK, and external EDC, drug distributor and drug supply forecasting systems, providing study teams with complete visibility of the clinical supply chain, from distributor to patients.

Through integration with Firecrest, Flex Advantage enables sponsors and investigators to log into a single ICON portal to capture electronic consent from patients and automatically continue to screen patients within the IRT database.