Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

(b) Departure of Certain Officers.

James Coffin, Ph.D., the President and Chief Operating Officer of Sema4 Holdings Corp. (the "Company"), will leave the Company for personal reasons, effective February 1, 2022.

(e) Compensatory Arrangements with Certain Officers.

In connection with Mr. Coffin's departure, the Company and Mr. Coffin have entered into a Separation Agreement (the "Separation Agreement"), pursuant to which Mr. Coffin will receive the following severance benefits in exchange for a customary release of claims against the Company:



•a severance payment equal to 12 months of Mr. Coffin's annual base salary;
•a discretionary 2021 annual bonus payment;
•12 months of reimbursement of COBRA continuation benefits;
•accelerated vesting of 25,425 stock options that were otherwise scheduled to
vest on February 2, 2022; and
•an extended period to exercise certain of Mr. Coffin's vested stock options
through May 30, 2022.

The foregoing description of the Separation Agreement does not purport to be complete and is qualified in its entirety by reference to the full text of the Separation Agreement, a copy of which is attached as Exhibit 10.1 and is incorporated herein by reference.




Item 9.01      Financial Statements and Exhibits.

(d) Exhibits.
     Exhibit
     Number                                        Description
      10.1          Separation Agreement with James Coffin dated as of January 25, 2022.
       104        Cover Page Interactive Data File (embedded within the Inline XBRL Document)
























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