Eckert & Ziegler and PharmaLogic Holdings Corp. have signed a reservation agreement for the supply of the therapeutic radioisotope Actinium-225 (Ac-225). Under the terms of the agreement, PharmaLogic will have access to Eckert & Ziegler's high-purity, non-carrier-added Actinium-225 for the labeling of radiopharmaceuticals for research and development work and commercial use.

Actinium-225 is used as an active substance in cancer treatment. The radioisotope emits powerful, high-energy alpha particles with short penetration depths, enabling precise treatment of tumor cells, including elusive micro-metastases, with minimal impact on surrounding healthy tissue. Clinical and market experts expect the demand of Actinium-225 to increase significantly over the next decade.

Eckert & Ziegler will establish GMP-compliant production of larger quantities of Ac-225 in 2024. Subsequently, the submission of a Drug Master File to the United States Food & Drug Administration is planned.