Creative Medical Technology Holdings, Inc. announced significant advances in the ongoing development of its ImmCelz (CELZ-100) platform, the Company's cell-free system which has previously been validated to supercharge a patient's own cells to treat a number of immune disorders. These advances support the Company's prior work in this area and confirm that the use of fewer donor cells can lower production costs while producing a more potent and efficacious final product. In particular, independent studies confirmed: That the ImmCelz ("CELZ-100) platforms required 75% fewer donor patient cells compared to industry standard; That the purity of the final ImmCelz(CELZ-100) product was greater than 95% compared to the industry standard of greater than 80%; That ImmCelz (CELZ -100) demonstrated a greater than 200% reduction in functional suppression of effector T cells, which are a critical concern for patients with autoimmune issues, while still possessing a high number of functional T regulatory cells; and The ability to verify repeated potency of the final ImmCelz-(CELZ-100) product.

All experiments were independently conducted and validated on selected human donor patient cells for accuracy and reproducibility.