Hong Kong Exchanges and Clearing Limited and The Stock Exchange of Hong Kong Limited take no responsibility for the contents of this announcement, make no representation as to its accuracy or completeness and expressly disclaim any liability whatsoever for any loss howsoever arising from or in reliance upon the whole or any part of the contents of this announcement.

CHARMACY PHARMACEUTICAL CO., LTD.

創美藥業股份有限公司

(A joint stock limited liability company incorporated in the People's Republic of China)

(Stock Code: 2289)

PROPOSED AMENDMENTS TO THE ARTICLES OF

ASSOCIATION AND THE RULES OF PROCEDURES FOR

SHAREHOLDERS' MEETINGS

On 29 November 2019, the Company proposed to amend the Articles of Association and the Rules of Procedures for Shareholders' Meetings, subject to the approval by the Shareholders at the EGM and the Class Meetings.

EGM AND CLASS MEETINGS

The EGM and Class Meetings (where applicable) will be held for the purposes of, among other things, seeking the approval of the Shareholders on (i) the proposed amendments to the Articles of Association and (ii) the proposed amendments to the Rules of Procedures for Shareholders' Meetings.

GENERAL

A circular containing, among other things, details of (i) the proposed amendments to the Articles of Association; (ii) the proposed amendments to the Rules of Procedures for Shareholders' Meetings; and (iii) the notices of the EGM, the Domestic Shareholders' Class Meeting and the H Shareholders' Class Meeting, will be despatched to the Shareholders as soon as practicable.

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On 29 November 2019, the Company proposed to amend the Articles of Association and the Rules of Procedures for Shareholders' Meetings, subject to the approval by the Shareholders at the EGM and the Class Meetings.

PROPOSED AMENDMENTS TO THE ARTICLES OF ASSOCIATION

Pursuant to the "Reply of the State Council on Adjustment of the Notice Period for General Meeting and Other Matters Applicable to Overseas Listed Company (國務院關於調整適用 在境外上市公司召開股東大會通知期限等事項規定的批覆)" (Guo Han [2019] No. 97), the requirements on the notice period, shareholders' proposal right and convening procedures for general meeting of joint stock companies incorporated in the PRC and listed overseas shall be governed by the relevant provisions under the Company Law of the PRC, instead of the provisions under Articles 20 to 22 of the "the Special Regulations of the State Council on the Overseas Offering and Listing of Shares by Joint Stock Limited Companies (國務院關 於股份有限公司境外募集股份及上市的特別規定)". Accordingly, on 29 November 2019, the Company proposed to amend the Articles of Association, subject to the approval by the Shareholders at the EGM and the Class Meetings, as follows:

Existing Articles

Proposed Amendments

Article 1.1

Article 1.1

C H A R M A C Y P H A R M A C E U T I C A L

C H A R M A C Y P H A R M A C E U T I C A L

CO., LTD. (hereinafter referred to as the

CO., LTD. (hereinafter referred to as the

"Company") is incorporated in accordance

"Company") is incorporated in accordance

with the Company Law of the People's

with the Company Law of the People's

Republic of China (hereinafter referred

Republic of China (hereinafter referred

to as the "Company Law"), the Special

to as the "Company Law"), the Special

Regulations on the Overseas Offering and

Regulations on the Overseas Offering and

Listing of Shares by Joint Stock Limited

Listing of Shares by Joint Stock Limited

Companies Promulgated by the State

Companies Promulgated by the State

Council of the People's Republic of China

Council of the People's Republic of China

(hereinafter referred to as the "Special

(hereinafter referred to as the "Special

Regulations") and other relevant laws and

Regulations "), the Reply of the State

regulations of the PRC.

Council on Adjustment of the Notice Period

for General Meeting and Other Matters

Applicable to Overseas Listed Company

(Guo Han [2019] No. 97)and other relevant

laws and regulations of the PRC.

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Article 6.9

Article 6.9

No change shall be made in the register

No change shall be made in the register

of shareholders as a result of a transfer of

of shareholders as a result of a transfer of

shares within 30 days prior to the date of

shares within 30 days prior to the date of

a shareholders' general meeting or within

a shareholders' general meeting or within

5 days before the record date for the

5 days before the record date for the

Company's distribution of dividends.

Company's distribution of dividends.Where

the relevant laws and regulations and the

Listing Rules of Hong Kong Stock Exchange

stipulate the period of closure of the register

of shareholders prior to a shareholders'

general meeting or the record date set by the

Company for the purpose of distribution of

dividends, such provisions shall prevail.

Article 8.6

Article 8.6

A 45-days written notice (the date on which

A 45-days written notice (the date on which

the notice is given is not included) for

the notice is given is not included) for

convening the shareholders' general meeting

convening the shareholders' general meeting

shall be served on the shareholders whose

shall be served on the shareholders whose

names appear in the register of shareholders

names appear in the register of shareholders

with the matters proposed to be considered

with the matters proposed to be considered

and the date and place of the meeting.

and the date and place of the meeting.

Shareholders who intend to attend the

Shareholders who intend to attend the

meeting shall send the written reply slip to

meeting shall send the written reply slip to

the Company 20 days prior to the date of the

the Company 20 days prior to the date of the

meeting.

meeting.

The calculation of the starting date shall not

To convene an annual general meeting of

include the date on which the meeting is

the Company, the Company shall notify all

convened.

shareholders by way of an announcement

the date and place of the meeting and

matters to be considered at the meeting, 20

clear business days prior to the meeting; to

convene an extraordinary general meeting,

the Company shall notify all shareholders by

way of an announcement 10 clear business

days or 15 days (whichever is longer) prior

to the meeting.

The calculation of the starting date shall not

include the date on which the meeting is

convened.

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Article 8.7

When the Company convenes an annual general meeting, shareholders holding 3% or more of the Company's shares with voting rights have the right to put forward new proposal(s) in writing to the Company, and the Company shall include such proposal(s) into the agenda for such general meeting if they are matters falls within the functions and powers of general meeting.

The shareholders solely or aggregately holding more than 3% of the Company's shares may make an interim draft resolution to the convener in writing 10 days before the convening of the shareholders' general meeting. The convener shall, within 2 days after the receipt of the draft resolution, issue a supplementary notice of shareholders' general meeting and announce the content of such interim draft resolution.

Article 8.7

When the Company convenes an annual general meeting, shareholders holding 3% or more of the Company's shares with voting rights have the right to put forward new proposal(s) in writing to the Company, and the Company shall include such proposal(s) into the agenda for such general meeting if they are matters falls within the functions and powers of general meeting.

The shareholders solely or aggregately holding more than 3% of the Company's shares may make an interim draft resolution to the convener in writing 10 days before the convening of the shareholders' general meeting. The convener shall, within 2 days after the receipt of the draft resolution, issue a supplementary notice of shareholders' general meeting and announce the content of such interim draft resolution. The content of the interim draft resolution shall fall within the scope of power of the shareholders' general meeting with clear discussion subject and a specific resolution, and shall comply with the relevant law, administrative regulations and the relevant requirements in these Articles.

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Article 8.8

The Company shall calculate the number of shares with voting rights represented by shareholders who intend to attend the meeting according to the written replies received as of 20 days prior to the convening of the shareholders' general meeting. Where the number of shares with voting rights represented by shareholders who intend to attend the meeting exceeds 1/2 of the total number of shares with voting rights of the Company, the Company may convene a shareholders' general meeting; if not, the Company shall, within 5 days thereafter, again notify, in the form of announcement, shareholders of the matters to be considered at the meeting and the date and place of the meeting; only after such notice in the form of announcement, the Company may convene the shareholders' general meeting.

No matters unspecified in the notice may be decided at the extraordinary general meeting.

Article 8.8

The Company shall calculate the number of shares with voting rights represented by shareholders who intend to attend the meeting according to the written replies received as of 20 days prior to the convening of the shareholders' general meeting. Where the number of shares with voting rights represented by shareholders who intend to attend the meeting exceeds 1/2 of the total number of shares with voting rights of the Company, the Company may convene a shareholders' general meeting; if not, the Company shall, within 5 days thereafter, again notify, in the form of announcement, shareholders of the matters to be considered at the meeting and the date and place of the meeting; only after such notice in the form of announcement, the Company may convene the shareholders' general meeting.

No matters unspecified in the notice or the supplemental noticemay be decided at the extraordinaryshareholders'general meeting.

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Article 8.10

The notice of shareholders' general meeting shall be delivered to shareholders (whether or not entitled to vote thereat) by hand or by prepaid post at their respective addresses which appear on the register of members. As for holders of domestic shares, the notice of the shareholders' general meeting may also be given by way of announcement.

T h e a n n o u n c e m e n t m e n t i o n e d i n t h e foregoing paragraph shall be published in one or more newspapers designated by the securities governing authority under the State Council within the interval between 45 days and 50 days prior to the meeting. Once the announcement is made, all the holders of domestic shares shall be deemed to have received the notice of the relevant shareholders' general meeting. The notices of the shareholders' general meeting delivered to the shareholders of overseas listed foreign shares may be given by the website of Hong Kong Stock Exchange or published in one or more newspapers designated by it. Once the announcement is made, all the shareholders of overseas listed foreign shares shall be deemed to have received the notice of the relevant shareholders' general meeting.

Article 8.10

The notice of shareholders' general meeting shall be delivered to shareholders (whether or not entitled to vote thereat) by hand or by prepaid post at thetheirrespective addresses of the receiverswhichappear on the register of members. As for holders of domestic shares, the notice of the shareholders' general meeting may also be given by way of announcement.

T h e a n n o u n c e m e n t m e n t i o n e d i n t h e foregoing paragraph shall be published in one or more newspapers designated by the securities governing authority under the State Council within the interval between 45 days and 50 days prior to the meeting. Once the announcement is made, all the holders of domestic shares shall be deemed to have received the notice of the relevant shareholders' general meeting. The notices of the shareholders' general meeting delivered to the shareholders of overseas listed foreign shares may be given through the website of Hong Kong Stock Exchange or published in one or more newspapers designated by it. Once the announcement is made, all the shareholders of overseas listed foreign shares shall be deemed to have received the notice of the relevant shareholders' general meeting.

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Article 8.28

At a general meeting, the approach and procedures for nomination of candidates for directors and supervisors are as follows:

  1. shareholder(s) severally or jointly holding more than 3% of the total outstanding issued shares with voting rights of the Company may, by way of a written proposal, put forward to the general meeting about the candidates for directors and supervisors (not being staff representatives). However, the number of candidates proposed shall comply with the provisions of the Articles of Association, and shall not exceed the number of the candidates to be elected. The aforesaid proposal put forward by shareholders to the Company should be served to the Company at least 14 days before the convening of the general meeting.

Article 8.28

At a general meeting, the approach and procedures for nomination of candidates for directors and supervisors are as follows:

  1. shareholder(s) severally or jointly holding more than 3% of the total outstanding issued shares with voting rights of the Company may, by way of a written proposal, put forward to the general meeting about the candidates for directors and supervisors (not being staff representatives). However, the number of candidates proposed shall comply with the provisions of the Articles of Association, and shall not exceed the number of the candidates to be elected. The aforesaid proposal put forward by shareholders to the Company should be served to the Company at least 1410days before the convening of the general meeting.

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Article 9.6

A written notice of a class shareholders' meeting shall be given to all shareholders who are registered as holders of that class in the register of members 45 days before the date of the meeting. Such notice shall give such shareholders notice of the matters to be considered at such meeting, the date and the place of the meeting. A shareholder who intends to attend the meeting shall deliver his written reply in respect thereof to the Company 20 days before the date of the class shareholders' meeting.

If the shareholders who intend to attend such class shareholders' meeting represent more than half of the total number of shares of that class with voting rights at such meeting, the Company may convene and hold the class shareholders' meeting; if not, the Company shall within 5 days give the shareholders further notice of the matters to be considered, the date and the place of the meeting by way of public announcement. The Company may then hold the class shareholders' meeting after such public announcement has been made.

Article 9.6

To conveneA written notice ofa class shareholders' meeting of the Company, the Company shall notifyshall be given toall shareholders who are registered as holders of that class in the register of members by notice in accordance with Article 8.6 of these Articles in relation to the requirements for convening extraordinary general meeting. Such notice shall give such shareholders notice of the matters to be considered at such meeting, the date and the place of the meeting. A shareholder who intends to attend the meeting shall deliver his written reply in respect thereof to the Company 20 days before the date of the class shareholders' meeting.

If the shareholders who intend to attend such class shareholders' meeting represent more than half of the total number of shares of that class with voting rights at such meeting, the Company may convene and hold the class shareholders' meeting; if not, the Company shall within 5 days give the shareholders further notice of the matters to be considered, the date and the place of the meeting by way of public announcement. The Company may then hold the class shareholders' meeting after such public announcement has been made.

The English version of the above Articles to the Articles of Association is an unofficial translation of its Chinese version. In case of any discrepancy between the two versions, the Chinese version shall prevail.

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P R O P O S E D A M E N D M E N T S T O T H E R U L E S O F P R O C E D U R E S F O R SHAREHOLDERS' MEETINGS

In view of the "Reply of the State Council on Adjustment of the Notice Period for General Meeting and Other Matters Applicable to Overseas Listed Company (國務院關於調整適用 在境外上市公司召開股東大會通知期限等事項規定的批覆)" (Guo Han [2019] No. 97), on 29 November 2019, the Company also proposed to amend the Rules of Procedures for Shareholders' Meetings, subject to the approval by the Shareholders at the EGM and the Class Meetings and the aforementioned amendments of the Articles of Association, as follows:

Existing Provisions

Proposed Amendments

Provision 1

Provision 1

In order to safeguard the legitimate rights

In order to safeguard the legitimate rights

and interests of all shareholders; regulate the

and interests of all shareholders; regulate the

conduct of Charmacy Pharmaceutical Co.,

conduct of Charmacy Pharmaceutical Co.,

Ltd. (the "Company"); ensure the regulated

Ltd (the "Company"); ensure the regulated

and efficient operation of the shareholders'

and efficient operation of the shareholders'

general meeting; and ensure the equal and

general meeting; and ensure the equal and

efficient exercise of shareholders' rights,

efficient exercise of shareholders' rights,

the Company formulated these rules in

the Company formulated such rules and

accordance with the Company Law of the

procedures in accordance with the Company

People's Republic of China ("Company

Law of the People's Republic of China

Law"), the Securities Law of the People's

("Company Law"), the Securities Law of

Republic of China, the Special Provisions of

the People's Republic of China, the Special

the State Council on the Raising of Shares

Provisions of the State Council on the

and Listings of Overseas Stocks and other

Raising of Shares and Listings of Overseas

laws, regulations and rules monitoring

Stocks, the Reply of the State Council on

a n d r e g u l a t i n g d o m e s t i c a n d f o r e i g n

Adjustment of the Notice Period for General

listed companies, as well as the articles of

Meeting and Other Matters Applicable to

association of the Company (the "Articles of

Overseas Listed Company (Guo Han [2019]

Association").

No. 97)and other laws, regulations and

rules monitoring and regulating domestic

and foreign listed companies, as well as the

articles of association of the Company (the

"Articles of Association").

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Provision 20

E x c e p t a s o t h e r w i s e p r o v i d e d i n t h e relevant provisions of the listing rules in the jurisdiction(s) where the securities of the Company are listed, a written notice of a shareholders' meeting shall be given to all shareholders who are registered as holders of the shares in the register of members 45 days before the date of the meeting (the date on which the notice is given and the date of the meeting are not included). Such notice shall give such shareholders notice of the matters to be considered at such meeting, the date and the place of the meeting. A shareholder who intends to attend the meeting shall deliver his written reply in respect thereof to the Company 20 days before the date of the shareholders' meeting.

The Company shall calculate the number of shares with voting rights represented by shareholders who intend to attend the meeting according to the written replies received as of 20 days prior to the convening of the shareholders' general meeting. If the shareholders who intend to attend such shareholders' meeting represent more than half of the total number of shares with voting rights at such meeting, the Company may convene and hold the shareholders' meeting; if not, the Company shall within 5 days give the shareholders further notice of the matters to be considered, the date and the place of the meeting by way of public announcement. The Company may then hold the shareholders' meeting after such public announcement has been made.

Provision 20

E x c e p t a s o t h e r w i s e p r o v i d e d i n t h e relevant provisions of the listing rules in the jurisdiction(s) where the securities of the Company are listed, to convene an annual general meeting of the Company, the Company shall notify all shareholders by way of an announcement the date and place of the meeting and matters to be considered at the meeting, 20 clear business days prior to the meeting (excluding the date of the meeting and the date on which the notice is issued); to convene an extraordinary general meeting, the Company shall notify all shareholders by way of an announcement 10 clear business days or 15 days (whichever is longer) prior to the meeting (excluding the date of the meeting and the date on which the notice is issued).a written notice of a shareholders' meeting shall be given to all shareholders who are registered as holders of the shares in the register of members 45 days before the date of the meeting (the date on which the notice is given and the date of the meeting are not included). Such notice shall give such shareholders notice of the matters to be considered at such meeting, the date and the place of the meeting. A shareholder who intends to attend the meeting shall deliver his written reply in respect thereof to the Company 20 days before the date of the shareholders' meeting.

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No matters unspecified in the notice may be decided at the extraordinary general meeting.

The Company shall calculate the number of shares with voting rights represented by shareholders who intend to attend the meeting according to the written replies received as of 20 days prior to the convening of the shareholders' general meeting. If the shareholders who intend to attend such shareholders' meeting represent more than half of the total number of shares with voting rights at such meeting, the Company may convene and hold the shareholders' meeting; if not, the Company shall within 5 days give the shareholders further notice of the matters to be considered, the date and the place of the meeting by way of public announcement. The Company may then hold the shareholders' meeting after such public announcement has been made.

No matters unspecified in the notice or the supplemental noticemay be decided at the extraordinaryshareholders'general meeting.

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Provision 21

The notice of shareholders' general meeting shall be delivered to shareholders (whether or not entitled to vote thereat) by hand or by prepaid post at the respective addresses of the receivers appear on the register of members. As for holders of domestic shares, the notice of the shareholders' general meeting may also be given by way of announcement.

T h e a n n o u n c e m e n t m e n t i o n e d i n t h e foregoing paragraph shall be published in one or more newspapers designated by the securities governing authority under the State Council within the interval between 45 days and 50 days prior to the meeting. Once the announcement is made, all the holders of domestic shares shall be deemed to have received the notice of the relevant shareholders' general meeting. The notices of the shareholders' general meeting delivered to the shareholders of overseas listed foreign shares may be given through the website of Hong Kong Stock Exchange or published in one or more newspapers designated by it. Once the announcement is made, all the shareholders of overseas listed foreign shares shall be deemed to have received the notice of the relevant shareholders' general meeting.

Provision 21

The notice of shareholders' general meeting shall be delivered to shareholders (whether or not entitled to vote thereat) by hand or by prepaid post at the respective addresses of the receivers appear on the register of members. As for holders of domestic shares, the notice of the shareholders' general meeting may also be given by way of announcement.

T h e a n n o u n c e m e n t m e n t i o n e d i n t h e foregoing paragraph shall be published in one or more newspapers designated by the securities governing authority under the State Council within the interval between 45 days and 50 days prior to the meeting. Once the announcement is made, all the holders of domestic shares shall be deemed to have received the notice of the relevant shareholders' general meeting. The notices of the shareholders' general meeting delivered to the shareholders of overseas listed foreign shares may be given through the website of Hong Kong Stock Exchange or published in one or more newspapers designated by it. Once the announcement is made, all the shareholders of overseas listed foreign shares shall be deemed to have received the notice of the relevant shareholders' general meeting.

The English version of the above provisions of the Rules of Procedures for Shareholders' Meetings is an unofficial translation of its Chinese version. In case of any discrepancy between the two versions, the Chinese version shall prevail.

EGM AND CLASS MEETINGS

The EGM and Class Meetings (where applicable) will be held for the purposes of, among others, seeking the approval of the Shareholders on (i) the proposed amendments to the Articles of Association; and (ii) the proposed amendments to the Rules of Procedures for Shareholders' Meetings.

Pursuant to Rule 13.39(4) of the Listing Rules, all votes at the EGM will be taken by poll and the Company will announce the results of the poll in the manner prescribed under Rule 13.39(5) of the Listing Rules.

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GENERAL

A circular containing, among other things, details of (i) the proposed amendments to the Articles of Association; (ii) the proposed amendments to the Rules of Procedures for Shareholders' Meetings; and (iii) the notices of the EGM, the Domestic Shareholders' Class Meeting and the H Shareholders' Class Meeting, will be despatched to the Shareholders as soon as practicable.

DEFINITIONS

Unless the context otherwise requires, the following expressions in this announcement have the following meanings:

"Articles of Association"

the articles of association of the Company, as amended from

time to time

"Board"

the board of Directors

"Company"

Charmacy Pharmaceutical Co., Ltd. (創美藥業股份有限

公司), a joint stock company established in the PRC with

limited liability, whose H Shares are listed and traded on the

main board of the Stock Exchange (stock code: 2289)

"Class Meeting(s)"

the H Shareholders' Class Meeting and/or the Domestic

Shareholders' Class Meeting (as the case may be)

"Director(s)"

the director(s) of the Company

"Domestic Share(s)"

the ordinary share(s) in the share capital of the Company

with a nominal value of RMB1.00 each, which are subscribed

for or credited as paid up in RMB by PRC nationals and/or

PRC corporate entities

"Domestic Shareholder(s)"

holder(s) of Domestic Share(s)

"Domestic Shareholders'

the class meeting of the holders of Domestic Shares to be

Class Meeting"

convened to consider, if appropriate, to approve, among

other things, the proposed amendments to the Articles of

Association and the Rules of Procedures for Shareholders'

Meetings

"EGM"

the extraordinary general meeting of the Company to be

convened to consider, if appropriate, to approve, among

other things, the proposed amendments to the Articles of

Association and the Rules of Procedures for Shareholders'

Meetings

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"Group"

the Company and its subsidiaries

"Hong Kong"

the Hong Kong Special Administrative Region of the PRC

"H Share(s)"

overseas listed foreign invested shares in the share capital

of the Company, which are listed on the main board of the

Stock Exchange with a nominal value of RMB1.00 each

"H Shareholders' Class

the class meeting of the holders of H Shares to be convened

Meeting"

to consider, if appropriate, to approve, among other things,

the proposed amendments to the Articles of Association and

the Rules of Procedures for Shareholders' Meetings

"Listing Rules"

the Rules Governing the Listing of Securities on the Stock

Exchange

"PRC"

The People's Republic of China, for the purpose of this

announcement, excluding Hong Kong, the Macau Special

Administrative Region of the PRC and Taiwan

"RMB"

Renminbi, the lawful currency of the PRC

"Rules of Procedures for

the Rules of Procedures for Shareholders' Meetings of the

Shareholders' Meetings"

Company, as amended from time to time

"Share(s)"

the Domestic Share(s) and/or the H Share(s)

"Shareholder(s)"

holder(s) of the Share(s)

"Stock Exchange"

The Stock Exchange of Hong Kong Limited

By order of the Board

Charmacy Pharmaceutical Co., Ltd.

Yao Chuanglong

Chairman

Shantou, the PRC, 29 November 2019

As at the date of this announcement, the executive Directors are Mr. Yao Chuanglong, Ms. Zheng Yuyan and Mr. Lin Zhixiong; the non-executive Director is Mr. Li Weisheng; and the independent non-executive Directors are Mr. Wan Chi Wai Anthony, Mr. Zhou Tao and Mr. Guan Jian (also known as Guan Suzhe)

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Chuangmei Pharmaceutical Co. Ltd. published this content on 29 November 2019 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 29 November 2019 14:07:02 UTC