On December 15, 2022, Caribou Biosciences, Inc. appointed Jason V. O'Byrne, its Chief Financial
Officer, as the Company's principal accounting officer. The Company's Vice President of Finance and Controller, Ryan Fischesser, who was previously serving as the
Company's principal accounting officer, will continue serving as the Company's Vice President of Finance and
Controller but not as the Company's principal accounting officer, effective as of December 15, 2022. The Board
of Directors of the Company determined that, due to the change in the Company's principal accounting officer,
effective December 15, 2022, Ryan Fischesser, the Company's Vice President of Finance and Controller, is no
longer an officer" for purposes of Section 16 of the Securities Exchange Act of 1934, as amended.