Janssen Biotech, Inc. announced that the company has entered a clinical trial collaboration with Bristol-Myers Squibb Company to evaluate the combination of the first CD38-directed cytolytic antibody daratumumab (DARZALEX®) and checkpoint inhibitor nivolumab (OPDIVO®) in Phase 1b/Phase 2 clinical studies in multiple myeloma and several solid tumor types. Nivolumab is developed and commercialized by BMS. Janssen licensed daratumumab from Genmab A/S and is responsible for all global development, marketing and manufacturing. The multiple myeloma study will evaluate the safety and tolerability of daratumumab in combination with nivolumab with or without pomalidomide and dexamethasone in relapsed/refractory multiple myeloma. The solid tumor studies will evaluate the safety, tolerability and clinical benefit of daratumumab combined with nivolumab in patients with advanced or metastatic tumors, including non-small cell lung, head and neck, pancreatic, colorectal and triple negative breast cancers. Additional tumor types may also be evaluated. Studies are expected to start in 2017.