BioNTech : Annual Report 2022 with the Consolidated Financial Statements as of 31 December 2022, the Combined Management Report for BioNTech SE and the Group and the Report of the Supervisory Board for the 2022 financial year

BioNTech | Annual Report 2022

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tomorrow

BioNTech Annual Report 2022

BioNTech | Annual Report 2022

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BioNTech | Annual Report 2022

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DNA sequencing

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Deoxyribonucleic acid ("DNA") is the biological molecule that carries genetic information as a code. It consists of four different building blocks called nucleotides, often referred to by the first letters of their chemical names: A, T, C and G. DNA is essential for the development and functioning of living organisms.

Decoding the sequence of DNA is key to understanding the function of genes and other parts of the genome. To determine the exact sequence of nucleotides, a laboratory technique called DNA sequencing is used. There are different methods to sequence DNA. The Sanger sequencing method, which

is illustrated in the picture, has existed for approximately forty years and is widely used. The shown fluorescent bands of different colors represent the four different nucleo- tides, illustrating their position in the DNA sequence. This way, the genetic code of a cell can be determined.

Differences between DNA sequences of a patient's healthy and tumor cells are a prerequisite for creating personalized therapies tailored to the individual tumor. We at BioNTech use next-generation sequencing to identify targets for personalized mRNA-based vaccines.

BioNTech | Annual Report 2022

Our pipeline

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MAGAZINE
Milestones 2022
	36

Turning our vision into reality	09
BioNTech by the numbers	11
Our pipeline	13
Board letter	17
Report of the Supervisory Board
on the 2022 financial year	25
Milestones 2022	36
Innovative pipeline -
Platform approaches and
synergistic combinations	48
Our commitment -
to better healthcare worldwide	64
BioNTech 2.0 -
Organizational structures
for holistic growth	74

48

Innovative pipeline - Platform approaches and synergistic combinations

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Our commitment - to better healthcare worldwide

64

BioNTech 2.0 - Organizational structures for holistic growth

74

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REPORT			Group report 2022				Further information
		137
					267
FINANCIAL					Remuneration report 2022
Combined management report 2022
	88			235

Independent auditor's report consolidated financial statements

Independent auditor's report remuneration report

Financial calendar 2023

Imprint

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TOMORROW

TOGETHER FOR A HEALTHIER

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Together for

1. healthier tomorrow

Lymphocytes are a type of white blood cell that form part

of the immune system. They work together to eliminate threats. Lymphocytes include cells that can directly eliminate threats, such as Natural Killer cells and T cells. Lymphocytes also comprise B cells, which produce antibodies. Antibodies are molecules that impair the function of the pathogen or the cancer cell and mark them for elimination.

BioNTech | Annual Report 2022

Turning our vision

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A GLOBAL

NEXT-GENERATION

IMMUNOTHERAPY COMPANY

into reality

We at BioNTech aim to strengthen and further develop our position as a global immunotherapy powerhouse. To this end, our strategy is focused on three priorities:

INNOVATIVE AND DIVERSIFIED PIPELINE

Develop potent and precise medicines to address diseases with high unmet medical needs

HEALTHCARE	INNOVATION
AND SOCIETAL	AT SCALE
RESPONSIBILITY
Contribute to democratize	Establishing and fostering
access to novel medicines	specific organizational
around the globe	structures for holistic
	growth

• Pipeline
• Societal responsibility
• Innovation at scale

The foundation for these priorities lies in our corporate values, unique culture, vision and spirit: We aspire to translate science into survival by developing new immunotherapies and vaccines utilizing the full potential of the immune system.

VISION MISSION

The foundation for our strategy are our corporate values,

unique BioNTech culture, vision and spirit.

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