Biome Australia Limited has received the pre-publication results of the Biome Lift Probiotic clinical trial (trial) taking place at La Trobe University in Melbourne. This trial investigated the effect of the Company's product Biome Lift Probiotic compared to placebo on the severity of depressive symptoms in 39 patients with subthreshold depression over a 12-week intervention period. Biome Lift Probiotic is currently sold within the community pharmacy and healthcare practitioner channels across Australia, New Zealand and the United Kingdom.

The formulation found in Biome Lift Probiotic has been the subject of two previous studies, and this latest study builds upon their findings and further strengthens this product's supporting clinical evidence. According to the researchers, these latest results provide evidence on the effectiveness of Biome Lift Probiotic in reducing the severity of depressive symptoms in patients with subthreshold depression. These findings, which are the culmination of a strategic research partnership with La Trobe University, reinforce the positive impacts this product can have and highlight additional benefits it can offer.

Biome has now received results of the: Self-report questionnaire-based assessment tools, which were used to assess the depression, mood, anxiety, stress and quality of life scores of participants before, during and after the intervention period. Blood samples, which were used to assess changes in biochemical markers of the glycemic profile, inflammation and oxidative stress of participants before, during and after the intervention period. Saliva samples, which were used to assess the change in a biochemical marker of stress before, during and after the intervention period.

Faecal samples, which were used to assess compositional and metagenomic changes in the gut microbiota of participants before, during and after the intervention period. Anthropometric and dietary intake data recorded before, during and after the intervention period, which were used to monitor for confounding effects on the study outcomes.