On June 14, 2023, Steven Ortega notified Applied Therapeutics, Inc. (the “Company”) that he will resign from his position as the Company’s Chief Accounting Officer and Interim Principal Financial Officer effective as of June 30, 2023, to pursue another professional opportunity. On June 16, 2023, the Company appointed Catherine Thorpe as the interim Principal Financial Officer and Chief Accounting Officer, effective immediately, in light of Mr. Ortega’s anticipated departure and Mr. Ortega ceased to serve in such roles. On June 16, 2023, the Company entered into an engagement letter (the “Engagement Letter”) with CFGI to assist the Company with, among other things, financial, accounting and tax consulting services as required by the Company.

Ms. Thorpe, an employee of CFGI, will be responsible for the Company’s accounting and finance functions and will serve as the Company’s Interim Principal Financial Officer and Chief Accounting Officer. The Engagement Letter may be terminated by the Company or CFGI at any time, for any reason, with 30 days prior written notice to the other party. Ms. Thorpe, age 60, served in the role of Managing Director at CFGI from April 2018 to January 2020 and has been the CFGI Stamford Office Managing Partner since January 2020.