Viromed Medical AG launched a second pioneering study on the use of cold plasma for the prevention of ventilator-associated pneumonia (VAP). The study, under the scientific direction of Prof. Dr. Hortense Slevogt from the Hannover Medical School (MHH) and two other world-renowned institutes, aims to obtain rapid special approval for the PulmoPlas device developed by Viromed for this innovative preventive measure in Germany and the USA. The further development and standardization of cold plasma technology for use in study-relevant cell cultures and later also in the human lung comes from relyon plasma GmbH, a wholly owned subsidiary of TDK Electronics AG.

As a partner of Viromed, relyon plasma will establish the prototypes for the application and ensure the standardized generation of cold plasma as well as its characterization and consistency in the trial. The exploitation rights are held by Viromed Medical AG. VAP is a frequent and serious complication in mechanically ventilated patients.

It occurs in patients who are invasively mechanically ventilated for at least 48 hours. Studies show that VAP occurs in 23% to 36% of mechanically ventilated patients and is associated with prolonged ventilation time and longer stays in the intensive care unit and hospital. The estimated mortality rate is 10% to 13%.

In Germany alone, there were around 486,000 mechanically ventilated intensive care patients in 2023 and many thousands of deaths, with a strong upward trend. Many millions of patients worldwide are mechanically ventilated every year. The use of cold plasma against VAP would therefore have the potential to save hundreds of thousands of lives every year.

Since October 2023, the MHH, in cooperation with Viromed Medical AG, has been investigating the safety profile of the use of cold plasma in bacterial infections of the respiratory tract using models of the respiratory mucosa. In particular, the focus is on the potential of cold plasma to kill bacteria that have infected the epithelium. In parallel, possibly associated inflammatory reactions, possible changes in cell differentiation, cell death, DNA damage as well as the therapeutic dose and the time window of application are being investigated.

In order to optimize the effectiveness of different plasma compositions, their effectiveness in connection with cell damage will be investigated differentially. Due to promising preliminary results that have shown no damaging effect on the airway epithelium, a second study is now starting in parallel, which was originally planned for mid-2025. This will expand the investigation of the safety profile of cold plasma on alveolar epithelium, taking into account mechanical shear forces that act on the alveolar mucosa during breathing.

In addition, the potential and safety of cold plasma to kill bacteria applied to precision-cut lung slices (PCLS) will be tested.