Used as a way to measure normal biological processes in the body, pathological processes, or the response of the body to a therapeutic intervention, Biomarkers have become an essential part of clinical development because they potentially offer a faster route to market versus the conventional drug development approach, where success rates have steadily declined in recent years. Attrition rates for drugs in discovery and development are currently very high with less than 10% of tested products entering phase I trials. With increasing costs involved in the drug development process, and growing concern that fewer drugs are making it through to the marketplace each year, the pharmaceutical industry is embracing biomarkers as a way of predicting a drug candidate's performance early and with a greater degree of certainty.
"The FDA, as well as academic and research organizations, have recognized Biomarkers as having great potential to speed the development and approval of medical products," said
"Biomarkers such as Her2 have already shown their effectiveness and benefit in clinical trials," said
Thomson Reuters has expanded the availability of BIOMARKERcenter, its unique comprehensive resource for biomarker intelligence. BIOMARKERcenter is now available through several delivery options: as a subscription option to users of Prous Science Integrity(R), as an XML feed for in-house bioinformatics solutions and also as a standalone web application. This solution covers biomarkers identified in literature, patents, conferences, clinical trial information, and other sources for all major therapeutic areas and is the first to provide the pharmaceutical industry with a framework for assessing the potential of a biomarker. BIOMARKERcenter is the most comprehensive resource of its kind and continues to expand rapidly, with more than 2,000 different biomarkers, and 13,000 unique uses of these biomarkers within its database.
For further information about BIOMARKERcenter, please go to: http://scientific.thomsonreuters.com/products/biomarkercenter/
To read the full white paper, "Biomarkers: an indispensable addition to the drug development toolkit," please register online at: http://scientific.thomsonreuters.com/forms/biomarkers/
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