On October 16, 2018, James Glasheen, MA, PhD resigned as a director from the Board of Directors (the Board) of Soleno Therapeutics, Inc. as well as from the Compensation Committee of the Board of Directors (the Compensation Committee) and the Audit Committee of the Board of Directors (the Audit Committee). The resignation of Dr. Glasheen was not the result of any disagreement with the Company relating to the company's operations, policies or practices. In addition, on October 19, 2018, Rajen Dalal resigned from the Compensation Committee and was appointed to serve on the Audit Committee and also appointed as the Chairman of the Nominating and Corporate Governance Committee of the Board of Directors.